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Sorted By Test Name - Mayo Medical Laboratories

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PHIV<br />

88635<br />

genotypic mutations present, according to the opinion of the consensus panel of leading experts in the<br />

field of HIV resistance. -"Unable to genotype" result indicates that the sequence data obtained are of poor<br />

quality to determine the presence or absence of genotypic resistant mutations in the patient's HIV strain.<br />

Possible causes of such poor sequence data include low HIV viral load (ie BCO value for the given drug.<br />

-"Maximal response" indicates that the predicted FC in IC50 is < or =CCO1 value for the specific drug.<br />

-"Reduced response" indicates that the predicted FC in IC50 is >CCO1 but < or =CCO2 values for the<br />

specific drug. -"Minimal response" indicates that the predicted FC in IC50 is >CCO2 value for the<br />

specific drug.<br />

Reference Values:<br />

Not applicable<br />

Clinical References: 1. Hanna GJ: HIV-1 genotypic and phenotypic resistance. Clin Lab Med<br />

2002;22:637-649 2. Cavert W, Balfour HH: Detection of antiretroviral resistance in HIV-1. Clin Lab Med<br />

2003;23:915-928 3. Cohen CJ, Hunt S, Sension M, et al: A randomized trial assessing the impact of<br />

phenotypic resistance testing on antiretroviral therapy. AIDS 2002;16:579-588 4. Mazotta F, Caputo SL,<br />

Torti C, et al: Real versus virtual phenotype to guide treatment in heavily pretreated patients: 48-week<br />

follow-up of the Genotipo-Fenotipo di Resistenza (GenPheRex) trial. J Acquir Immune Defic Syndr<br />

2003;32:268-280 5. Perez-Elias MJ, Garcia-Arata I, MuAoz V, et al: Phenotype or virtual phenotype for<br />

choosing antiretroviral therapy after failure: a prospective, randomized study. Antivir Ther<br />

2003;8:577-584<br />

HIV-1 Proviral DNA Qualitative Detection by PCR, Blood<br />

Clinical Information: Human immunodeficiency virus (HIV)-1 infection in humans is usually<br />

confirmed by detection of HIV-1-specific antibodies in serum. However, serologic testing may not<br />

reliably identify HIV-1 infection in neonates with passively acquired maternal HIV-1 antibodies or with<br />

incompletely developed immune systems, in individuals with early infection (

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