Sorted By Test Name - Mayo Medical Laboratories

HHV6V
89888
HHV8
81971
Clinical References: 1. De Bolle L, Naesens L, De Clercq E: Update on human herpesvirus 6
biology, clinical features, and therapy. Clin Microbiol Rev 2005 Jan;18(1):217-245 2. Dockrell DH, Paya
CV: Human herpesvirus-6 and -7 in transplantation. Rev Med Virol 2001 Jan-Feb;11(1):23-36 3.
Abdel-Haq NM, Asmar BI: Human herpesvirus 6 (HHV6) infection. Indian J Pediatr 2004
Jan;71(1):89-96 4. Dockrell DH, Smith TF, Paya CV: Human herpesvirus 6. Mayo Clin Proc 1999
Feb;74(2):163-170
Human Herpesvirus-6, Molecular Detection, PCR, Varies
Clinical Information: Human herpesvirus-6 (HHV-6) is a member of the Herpesviridae family.
These viruses contain DNA surrounded by a lipid envelope. Among members of this group, this virus is
most closely related to cytomegalovirus (CMV) and HHV-7. As with other members of the herpesvirus
group (herpes simplex virus [HSV] 1, HSV 2, varicella zoster virus, CMV, Epstein-Barr virus, HHV-7,
HHV-8), HHV-6 may cause primary and reactivated infections subsequent to latent association with
cells.(1) Infection with HHV-6 occurs early in childhood. Most adults (80%-90%) have been infected
with this virus. HHV-6 was first linked with exanthem subitum (roseola infantum) in 1998; since then, the
virus has been associated with central nervous system disease almost exclusively in immunocompromised
patients.(1) HHV-6 is commonly detected in patients posttransplantation. Clinical symptoms associated
with this viral infection include febrile illness, pneumonitis, hepatitis, encephalitis, and bone marrow
suppression. However, the majority of HHV-6 infections are asymptomatic.(2) The incidence of HHV-7
infection and its clinical manifestations posttransplantation are less well characterized. HHV-6 is
designated as variant A (HHV-6A) or variant B (HH6-B) depending on restriction enzyme digestion
patterns and on its reaction with monoclonal antibodies. Generally, variant B has been associated with
exanthem subitum, whereas variant A has been found in many immunosuppressed patients.(3)
Useful For: As an adjunct in the rapid diagnosis of human herpesvirus-6 infection
Reference Values:
Not applicable
Clinical References: 1. De Bolle L, Naesens L, De Clercq E: Update on human herpesvirus 6
biology, clinical features, and therapy. Clin Microbiol Rev 2005 Jan;18(1):217-245 2. Dockrell DH, Paya
CV: Human herpesvirus-6 and -7 in transplantation. Rev Med Virol 2001 Jan-Feb;11(1):23-36 3.
Abdel-Haq NM, Asmar BI: Human herpesvirus 6 (HHV6) infection. Indian J Pediatr 2004
Jan;71(1):89-96 4. Dockrell DH, Smith TF, Paya CV: Human herpesvirus 6. Mayo Clin Proc 1999
Feb;74(2):163-170
Human Herpesvirus-8 Antibody, IgG, Serum
Clinical Information: Human herpesvirus-8 (HHV-8) infections are limited in the general
population. The virus was first discovered in Kaposi's sarcoma (KS) lesions and also is known as Kaposi's
sarcoma herpesvirus.(1) Endemic KS is common in sub-Saharan equatorial Africa, accounting for 10% to
17% of all adult malignancies. Elsewhere KS is rare, occurring primarily in Mediterranean and Eastern
European adults. In the United States, KS primarily affects acquired immunodeficiency syndrome (AIDS)
patients. Approximately 90% of KS tissues from AIDS patients contain HHV-8 DNA sequences. Sexual
transmission of human herpesvirus-8 (HHV-8) may be possible since HHV-8 DNA sequences have been
found in the semen of AIDS patients. HHV-8 also is associated with transplantation-associated KS, which
occurs in up to 5% of kidney transplant patients. Transmission of HHV-8 through renal allografts has
been shown to be a risk factor for transplantation-associated KS.(3,6) Patients who are negative for
antibodies to HHV-8 and receive transplanted organs from a donor who has antibodies to HHV-8 are at
increased risk for the development of KS post transplantation. HHV-8 also is associated with Bowenâ€s
disease, a malignant squamous cell carcinoma; primary effusion lymphoma; Castleman's disease; and
multiple myeloma.(1,4,5)
Useful For: Assessment of serostatus of organ transplant patients to Human Herpesvirus-8 before a
procedure to evaluate risk for transmission of virus and subsequent development of Kaposi's sarcoma
Current as of January 4, 2013 7:15 pm CST 800-533-1710 or 507-266-5700 or MayoMedicalLaboratories.com Page 978