Sorted By Test Name - Mayo Medical Laboratories

CARBA
81833
FCAR
81770
concentration of IgE antibodies expressed as a class score or kU/L.
Reference Values:
Class IgE kU/L Interpretation
0 Negative
1 0.35-0.69 Equivocal
2 0.70-3.49 Positive
3 3.50-17.4 Positive
4 17.5-49.9 Strongly positive
5 50.0-99.9 Strongly positive
6 > or =100 Strongly positive Reference values
apply to all ages.
Clinical References: Homburger HA: Allergic diseases. In Clinical Diagnosis and Management by
Laboratory Methods. 21st edition. Edited by RA McPherson, MR Pincus. New York, WB Saunders
Company, 2007, Chapter 53, Part VI, pp 961-971
Carbamazepine Profile
Reference Values:
CARBAMAZEPINE, TOTAL
Therapeutic concentration: 4.0-12.0 mcg/mL
Toxic concentration: > or =15.0 mcg/mL
CARBAMAZEPINE-10,11-EPOXIDE
Therapeutic concentration: 0.4-4.0 mcg/mL
Toxic concentration: > or =8.0 mcg/mL
CARBAMAZEPINE, FREE
Therapeutic concentration: 1.0-3.0 mcg/mL
Toxic concentration: > or =4.0 mcg/mL
Carbamazepine, Free and Total, Serum
Clinical Information: Carbamazepine (Tegretol) is an effective treatment for complex partial
seizures, with or without generalization to tonic-clonic seizures. It is frequently administered in
conjunction with other antiepileptic agents, such as phenytoin and valproic acid. Under normal
circumstances, the carbamazepine that circulates in blood is 75% protein bound. In severe uremia,
carbamazepine may be displaced from protein, resulting in a higher free (unbound) fraction of the drug
circulating in blood. Since neurologic activity and toxicity are directly related to the circulating free
fraction of drug, adjustment of dosage based on knowledge of the free carbamazepine level may be useful
in patients with severe uremia.
Useful For: Monitoring carbamazepine therapy in uremic patients
Interpretation: In patients with normal renal function, optimal response is often associated with free
(unbound) carbamazepine levels >1.0 mcg/mL, and toxicity may occur when the free carbamazepine is >
or =4.0 mcg/mL. In uremic patients, the free carbamazepine level may be a more useful guide for dosage
adjustments than the total level. In patients with severe uremia, subtherapeutic total carbamazepine levels
in the range of 1.0 to 2.0 mcg/mL may be associated with therapeutic free levels. Toxicity may occur in
these patients when the free carbamazepine level is > or =4.0 mcg/mL (even though the total
carbamazepine concentration is