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Sorted By Test Name - Mayo Medical Laboratories

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FAMPH<br />

90113<br />

AMPHU<br />

8257<br />

MJ, Parks PM, et al: Drug screening of meconium in infants of drug-dependent mothers: and alternative<br />

to urine testing. J Pediatr 1989;115:474-477 3. Ahanya SN, Lakshmanan J, Morgan BL, Ross MG:<br />

Meconium passage in utero: mechanisms, consequences, and management. Obstet Gynecol Surv<br />

2005;60:45-56 4. Kwong TC, Ryan RM: Detection of intrauterine illicit drug exposure by newborn drug<br />

testing. National Academy of Clinical Biochemistry. Clin Chem 1997;43:235-242 5. Dixon SD: Effects of<br />

transplacental exposure to cocaine and methamphetamine on the neonate. West J Med 1989;150:436-442<br />

Amphetamines Screen and GC-MS Confirmation, Serum -<br />

Forensic<br />

Reference Values:<br />

This specimen was screened by Immunoassay. Any positive result is<br />

confirmed by Gas Chromatography with Mass Spectrometry (GC/MS).<br />

The following threshold concentrations are used for this analysis:<br />

DRUG SCREENING CONFIRMATION<br />

THRESHOLD THRESHOLD<br />

Amphetamines 50 ng/mL<br />

Amphetamine 10 ng/mL<br />

Methamphetamine 10 ng/mL<br />

TEST PERFORMED BY<br />

MEDTOX LABORATORIES, INC.<br />

402 W. COUNTY ROAD D<br />

ST. PAUL, MN. 55112<br />

Amphetamines, Urine<br />

Clinical Information: Amphetamines are sympathomimetic amines that stimulate the central nervous<br />

system activity and, in part, suppress the appetite. Phentermine, amphetamine, and methamphetamine are<br />

prescription drugs for weight loss. All of the other amphetamines are Class I (distribution prohibited)<br />

compounds. In addition to their medical use as anorectic drugs, they are used in the treatment of<br />

narcolepsy, attention-deficit disorder/attention-deficit hyperactivity disorder and minimal brain<br />

dysfunction. Because of their stimulant effects, the drugs are commonly sold illicitly and abused.<br />

Physiological symptoms associated with very high amounts of ingested amphetamine or<br />

methamphetamine include elevated blood pressure, dilated pupils, hyperthermia, convulsions, and acute<br />

amphetamine psychosis.<br />

Useful For: Confirming drug exposure involving amphetamines such as amphetamine and<br />

methamphetamine, phentermine, methylenedioxyamphetamine (MDA),<br />

methylenedioxymethamphetamine (MDMA), and methylenediaoxyethylamphetamine (MDEA). MDA is<br />

a metabolite of MDMA and MDEA.<br />

Interpretation: The presence of amphetamines in urine at concentrations >500 ng/mL is a strong<br />

indicator that the patient has used these drugs within the past 3 days. This test will produce true-positive<br />

results for urine specimens collected from patients who are administered Adderall and Benzedrine<br />

(contain amphetamine); Desoxyn and Vicks Inhaler (contain methamphetamine); Selegiline (metabolized<br />

to methamphetamine and amphetamine); and clobenzorex, famprofazone, fenethylline, fenproporex, and<br />

mefenorex, which are amphetamine pro-drugs.<br />

Reference Values:<br />

Negative<br />

Positives are reported with a quantitative GC-MS result.<br />

Cutoff concentrations:<br />

IMMUNOASSAY SCREEN<br />

Current as of January 4, 2013 7:15 pm CST 800-533-1710 or 507-266-5700 or <strong>Mayo</strong><strong>Medical</strong><strong>Laboratories</strong>.com Page 126

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