Sorted By Test Name - Mayo Medical Laboratories

LEBV
81239
EBVB
87439
with type 1 NPC have a positive response. The specificity of the test is such that 82% to 91% of healthy
blood donor controls and patients who do not have NPC have negative responses (9% to 18%
false-positives). Although this level of specificity is useful for diagnostic purposes, the false-positive rate
indicates that the test is not useful for NPC screening.
Reference Values:
Negative
Clinical References: 1. Fields BN, Knipe DM: Epstein-Barr virus. In Fields Virology. 4th edition.
Edited by BN Fields, DM Knipe, PM Howley. Philadelphia, Lippincott Williams & Wilkins, 2001 2.
Lennette ET: Epstein-Barr virus. In Manual of Clinical Microbiology. 6th edition. Edited by PR Murray,
EJ Baron, MA Pfaller, et al. Washington, DC, American Society for Microbiology, 1995, pp 905-910
Epstein-Barr Virus (EBV), Molecular Detection, PCR
Clinical Information: Epstein-Barr virus (EBV) is the causative agent of infectious mononucleosis,
Burkitt's lymphoma, and in Southern China, nasopharyngeal carcinoma. EBV-associated central nervous
system (CNS) disease is most commonly associated with primary CNS lymphoma in patients with AIDS.
In addition, CNS infection associated with the detection of EBV DNA can be seen in immunocompetent
patients.
Useful For: Rapid qualitative detection of Epstein-Barr virus DNA in specimens for laboratory
diagnosis of disease due to this virus
Interpretation: Detection of Epstein-Barr virus (EBV) DNA in cerebrospinal fluid (CSF) supports the
clinical diagnosis of central nervous system (CNS) disease due to the virus. EBV DNA is not detected in
CSF from patients without CNS disease caused by this virus.
Reference Values:
Not applicable
Clinical References: 1. Tachikawa N, Goto M, Hoshino Y, et al: Detection of Toxoplasma gondii,
Epstein-Barr virus, and JC virus DNAs in the cerebrospinal fluid in acquired immunodeficiency syndrome
patients with focal central nervous system complications. Intern Med 1999;38(7):556-562 2. Antinori A,
Cingolani A, De Luca A, et al: Epstein-Barr virus in monitoring the response to therapy of acquired
immunodeficiency syndrome-related primary central nervous system lymphoma. Ann Neurol
1999;45(2):259-261 3. Niller HH, Wolf H, Minarovits J: Regulation and dysregulation of Epstein-Barr
virus latency: implications for the development of autoimmune disease. Autoimmunity
2008:41(4):298-328 4. Studahl M, Hagberg L, Rekvdar E, Bergstrom T: Herpesvirus DNA detection in
cerebrospinal fluid: difference in clinical presentation between alph-, beta-, and gamma-herpes viruses.
Scand J Infect Dis 2000;32(3):237-248 5. Lau AH, Soltys K, Sindhi RK, et al: Chronic high Epstein-Barr
viral load carriage in pediatric small bowel transplant recipients. Pediatr Transplant Jan 20
Epstein-Barr Virus (EBV), Molecular Detection, PCR, Blood
Clinical Information: Epstein-Barr virus (EBV) is the causative agent of infectious mononucleosis,
Burkitt's lymphoma, and in Southern China, nasopharyngeal carcinoma. EBV-associated central nervous
system (CNS) disease is most commonly associated with primary CNS lymphoma in patients with AIDS.
In addition, CNS infection associated with the detection of EBV DNA can be detected in
immunocompetent patients.
Useful For: Rapid qualitative detection of Epstein-Barr virus DNA in specimens for laboratory
diagnosis of disease due to this virus
Interpretation: Detection of Epstein-Barr virus supports the clinical diagnosis of disease due to the
virus.
Reference Values:
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