Sorted By Test Name - Mayo Medical Laboratories

AMIO
9247
dehydratase (ALAD) activity is typically reduced by 80%, or more, from normal levels. ALAD activity
can be inhibited in other situations including hereditary tyrosinemia type 1, lead intoxication, and
exposure to styrene, trichloroethylene, and bromobenzene. These causes should be ruled out when
considering a diagnosis of ADP.
Reference Values:
> or =4.0 nmol/L/sec
3.5-3.9 nmol/L/sec (indeterminate)
0.5 mcg/mL. Increased risk of
toxicity is associated with amiodarone concentrations >2.5 mcg/mL. Although therapeutic and toxic
ranges are based only on the parent drug, the active metabolite N-desethylamiodarone should be present
in similar concentrations to amiodarone.
Reference Values:
AMIODARONE
Therapeutic concentration: 0.5-2.0 mcg/mL
Toxic concentration: >2.5 mcg/mL
DESETHYLAMIODARONE
No therapeutic range established; activity and serum concentration are similar to parent drug.
Clinical References: 1. Goldschlager N, Epstein AE, Naccarelli GV, et al: A practical guide for
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