Sorted By Test Name - Mayo Medical Laboratories

FFTRA
91693
TNFN
300205
Company, 2007, Chapter 53, Part VI, pp 961-971
Tramadol (Ultram), Qualitative, Urine
Reference Values:
Test Performed By: Medtox Laboratories, Inc.
402 W. County Road D
St. Paul, MN 55112
Transferrin, Serum
Clinical Information: Transferrin is an iron-binding serum protein and can be readily assayed by
either measurement of immunologic reactivity or measurement of the total iron-binding capacity (TIBC).
Knowing the molecular weight of the transferrin and that each molecule of transferrin can bind 2 atoms of
iron, TIBC and transferrin concentration is interconvertible. All of the many known molecular variants of
transferrin have the same iron-binding function. Thus, at present, neither specific functional nor
immunologically altered transferrins have been identified that would result in spurious results when
transferrin is measured either immunologically or as TIBC. Changes in transferrin concentration occur in
response to an iron deficiency in chronic diseases among many other causes. The changes are of the same
direction and magnitude whether transferrin is measured immunologically or as the TIBC.
Useful For: Work-up of patients suspected of having congenital transferrin abnormalities An alternate
test to total iron-binding capacity (TIBC) Measurements in pediatric patients because of the small serum
specimen compared to the TIBC procedure
Interpretation: Severe iron deficiency can result in levels as high as 700 mg/dL. Levels as low as 40
mg/dL can be seen in protein losing states such as nephrotic syndrome. Congenital atransferrinemia in the
rare reported cases has been characterized by immunologically measured transferrin concentration of zero
and total iron-binding capacity very near zero.
Reference Values:
170-340 mg/dL
Clinical References: 1. Silverman LM, Christenson RH, Grant GH: Amino acids and proteins. In
Textbook of Clinical Chemistry. Edited by NW Tietz. Philadelphia, WB Saunders Company, 1986, pp
519-618 2. Ramsay WNM: The determination of the total iron binding capacity of serum. Clin Chim Acta
1957;1:221-226 3. Tsung SH, Rosenthal WA, Milewski KA: Immunological measurement of transferrin
compared with chemical measurement of total iron binding capacity. Clin Chem 1975;21:1063-1066 4.
Buffone GJ, Lewis SA, Iosefsohn M, Hicks JM: Chemical and immunochemical measurements of total
iron binding capacity compared. Clin Chem 1978;24:1788-1791 5. Markowitz H, Fairbanks VF:
Transferrin assay and total iron binding capacity. Mayo Clin Proc 1983;58:827-828 6. Siemens
Nephelometer II Operators Instruction Manual. Siemens, Inc., Newark, DE
800154 Transferrin, Serum
Clinical Information: Transferrin is an iron-binding serum protein and can be readily assayed by
either measurement of immunologic reactivity or measurement of the total iron-binding capacity (TIBC).
Knowing the molecular weight of the transferrin and that each molecule of transferrin can bind 2 atoms of
iron, TIBC and transferrin concentration are interconvertible. All of the many known molecular variants
of transferrin have the same iron-binding function. Thus, at present, neither specific functional nor
immunologically altered transferrins have been identified that would result in spurious results when
transferrin is measured either immunologically or as TIBC. Changes in transferrin concentration occur in
response to an iron deficiency in chronic diseases, among many other causes. The changes are in the same
direction and of the same magnitude whether transferrin is measured immunologically or as the TIBC.
Useful For: Work-up of patients suspected of having congenital transferrin abnormalities An alternate
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