Sorted By Test Name - Mayo Medical Laboratories

PBRU
60246
PBCRU
60247
significant lead exposure.
Reference Values:
0.0-3.9 mcg/g of nails
Reference values apply to all ages.
Clinical References: 1. Strumylaite L, Ryselis S, Kregzdyte R: Content of lead in human hair from
people exposed to lead. Int J Hyg Environ Health 2004;207:345-351 2. Barbosa F, Tanus-Santos J,
Gerlach R, Parsons P: A critical review of biomarkers used for monitoring human exposure to lead:
advantages, limitations, and future needs. Environ Health Perspect 2005;113:1669–1674 3. Sanna E,
Liguori A, Palmes L, et al: Blood and hair lead levels in boys and girls living in two Sardinian towns at
different risks of lead pollution. Ecotoxicol Environ Saf 2003;500:293-299
Lead, Random, Urine
Clinical Information: Increased urine lead concentration indicates significant lead exposure.
Measurement of urine lead concentration before AND after chelation therapy has been used as an
indicator of significant lead exposure. An increase in lead concentration in the postchelation specimen of
up to 6 times the concentration in the prechelation specimen is normal. Blood lead is the best clinical
correlate of toxicity. For additional information, see PBBD/15070 Lead with Demographics, Blood.
Useful For: Detecting clinically significant lead exposure
Interpretation: Urinary excretion of 4 mcg /L is usually associated with pallor, anemia, and other evidence of lead toxicity.
Reference Values:
0-4 mcg/L
Reference values apply to all ages.
Clinical References: 1. Kosnett MJ, Wedeen RP, Rotherberg SJ, et al: Recommendations for
medical management of adult lead exposure. Environ Health Perspect 2007;115:463-471 2. de Burbane C,
Buchet JP, Leroyer A, et al: Renal and neurologic effects of cadmium, lead, mercury, and arsenic in
children: evidence of early effects and multiple interactions at environmental exposure levels.Environ
Health Perspect 2006;114:584-590 3. Pascal DC, Ting BG, Morrow JC, et al: Trace metals in urine of
United States residents: reference range concentrations.Environ Res 1998;76(1):53-59
Lead/Creatinine Ratio, Random, Urine
Clinical Information: Increased urine lead concentration per gram of creatinine indicates significant
lead exposure. Measurement of urine lead concentration per gram of creatinine before AND after
chelation therapy has been used as an indicator of significant lead exposure. An increase in lead
concentration per gram of creatinine in the post chelation specimen of up to 6X the concentration in the
prechelation specimen is normal. Blood lead is the best clinical correlate of toxicity. For additional
information, see PBBD/15070 Lead with Demographics, Blood.
Useful For: Detecting clinically significant lead exposure
Interpretation: Urinary excretion of 4 mcg/g creatinine is usually associated with pallor, anemia, and other
evidence of lead toxicity.
Reference Values: