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PTHFN<br />

61526<br />

Females<br />

0-11 months: not established**<br />

1-7 years: 4.3-5.4 mg/dL<br />

8-13 years: 4.0-5.2 mg/dL<br />

14-15 years: 3.5-4.9 mg/dL<br />

16-17 years: 3.1-4.7 mg/dL<br />

> or =18 years: 2.5-4.5 mg/dL<br />

CREATININE<br />

Males<br />

0-11 months: not established<br />

1-2 years: 0.1-0.4 mg/dL<br />

3-4 years: 0.1-0.5 mg/dL<br />

5-9 years: 0.2-0.6 mg/dL<br />

10-11 years: 0.3-0.7 mg/dL<br />

12-13 years: 0.4-0.8 mg/dL<br />

14-15 years: 0.5-0.9 mg/dL<br />

> or =16 years: 0.8-1.3 mg/dL<br />

Females<br />

0-11 months: not established<br />

1-3 years: 0.1-0.4 mg/dL<br />

4-5 years: 0.2-0.5 mg/dL<br />

6-8 years: 0.3-0.6 mg/dL<br />

9-15 years: 0.4-0.7 mg/dL<br />

> or =16 years: 0.6-1.1 mg/dL<br />

*The serum concentration of calcium varies significantly during the immediate neonatal period. In<br />

general, the serum calcium concentration decreases over the first days of life, followed by a gradual<br />

increase to adult concentrations by the second or third week of life.<br />

**The plasma concentrations of inorganic phosphate in the neonatal period can be greater than those of<br />

the adult.<br />

Clinical References: 1. Boudou P, Ibrahim F, Cormier C, et al: Third- or second-generation<br />

parathyroid hormone assays: a remaining debate in the diagnosis of primary hyperparathyroidism. J Clin<br />

Endocrinol Metab 2005;90(12):6370-6372 2. Silverberg SJ, Bilezikian JP: The diagnosis and<br />

management of asymptomatic primary hyperparathyroidism. Nat Clin Pract Endocrinol Metab<br />

2006;2(9):494-503 3. Brossard JH, Cloutier M, Roy L, et al: Accumulation of a non-(1-84) molecular<br />

form of parathyroid hormone (PTH) detected by intact PTH assay in renal failure: importance in the<br />

interpretation of PTH values. J Clin Endocrinol Metab 1996;81:3923-3929 4. Garfield N, Karaplis AC:<br />

Genetics and animal models of hypoparathyroidism. Trends Endocrinol Metab 2001;12:288-294 5.<br />

Sakhaee K: Is there an optimal parathyroid hormone level in end-stage renal failure: the lower the better?<br />

Curr Opin Nephrol Hypertens 2001;10:421-427 6. Vetter T, Lohse MJ: Magnesium and the parathyroid.<br />

Curr Opin Nephrol Hypertens 2002;11:403-410 7. Bilezikian JP, Potts JT Jr, Fuleihan Gel-H, et al:<br />

Summary statement from a workshop on asymptomatic primary hyperparathyroidism: a perspective for<br />

the 21st century. J Clin Endocrinol Metab 2002;87:5353-5361<br />

Parathyroid Hormone, Fine-Needle Aspiration Biopsy<br />

(FNAB)-Needle Wash<br />

Clinical Information: Parathyroid hormone (PTH) is produced and secreted by the parathyroid<br />

glands, which are located along the posterior aspect of the thyroid gland. PTH analysis in rinse material<br />

obtained from fine-needle aspiration biopsies (FNAB) has gained popularity to discriminate thyroid<br />

tissues from enlarged parathyroid glands and also to facilitate parathyroid localization prior to surgery.<br />

Various groups have reported on the utility of this technique with specificity of 91% to100% and<br />

sensitivity of 91% to 100%. Measuring PTH in the rinse material proved very useful in cases of<br />

nondiagnostic cytology. Comparing the results of the PTH rinse material with serum PTH is highly<br />

Current as of January 4, 2013 7:15 pm CST 800-533-1710 or 507-266-5700 or <strong>Mayo</strong><strong>Medical</strong><strong>Laboratories</strong>.com Page 1368

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