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Sorted By Test Name - Mayo Medical Laboratories

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FFIL4<br />

90068<br />

FIL<br />

9232<br />

The detected circulating levels are very high, in a futile compensatory response to the hyperphosphatemia.<br />

Almost all patients with renal failure have elevated FGF23 levels, and FGF23 levels are inversely related<br />

to the likelihood of successful therapy with calcitriol or active vitamin D analogs. Definitive cutoffs<br />

remain to be established, but it appears that renal failure patients with FGF23 levels of >50 times the<br />

upper limit of the reference range have a low chance of a successful response to vitamin D analogues<br />

(900 RU/mL) in normal infants or =18 years: < or =180 RU/mL<br />

Clinical References: 1. Online Mendelian Inheritance of Man (OMIM) entry *605380 Fibroblast<br />

Growth Factor 23; FGF23, Retrieved 1/25/06, Available from URL:<br />

http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=605380 2. Yu X, White KE: FGF23 and disorders<br />

of phosphate homeostasis. Cytokine Growth Factor Rev 2005;16:221-232 3. Fukagawa M, Nii-Kono T,<br />

Kazama JJ: Role of fibroblast growth factor 23 in health and chronic kidney disease. Curr Opin Nephrol<br />

Hypertens 2005;14:325-329 4. Jan de Beur SM: Tumor-induced osteomalacia. JAMA<br />

2005;294:1260-1267 5. Tenenhouse HS: Regulation of phosphorus homeostasis by the type IIa<br />

Na/phosphate cotransporter. Ann Rev Nutr 2005;25:197-214<br />

Filaria IgG4 Antibody, ELISA<br />

Reference Values:<br />

REFERENCE RANGE:

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