Sorted By Test Name - Mayo Medical Laboratories

DISII
32864
HLA15
89347
Useful For: Determining class I human leukocyte antigens on specimens for transplant candidates and
their donors or those who have become refractory to platelet transfusions
Interpretation: Interpretation depends on the rationale for ordering the test. Assessments of acceptable
donor/recipient matches are made on a case-by-case basis.
Reference Values:
Not applicable
Clinical References: 1. Terasaki PI, Bernoco D, Park MS, et al: Microdroplet testing for HLA-A, B,
C and D antigens. Am J Clin Pathol 1978 Feb;69(2):103-120 2. Colinas RJ, Bellisario R, Pass KA:
Multiplexed genotyping of beta-globin variants form PCR-amplified newborn blood spot DNA by
hybridization with allele-specific oligodeoxynucleotides coupled to an array of fluorescent microspheres.
Clin Chem 2000 Jul;46(7):996-998
HLA Class II Molecular Typing Disease Association
Clinical Information: Human leukocyte antigens (HLA) are regulators of the immune response that
play a key role in transplantation. Class II HLA antigens are encoded by the D region of chromosome 6
and include DP, DQ, and DR. Sequence-specific oligonucleotides are designed to provide low-to-medium
resolution for HLA Class II (DR and DQ) typing. Low-to-medium resolution defines the typing at the
antigen level. This is in contrast to high-resolution typing, which defines typing at the allele (molecular)
level and is used primarily for typing donor-recipient pairs for unrelated bone marrow transplantation.
Useful For: Determining human leukocyte antigens class II compatibility on specimens from bone
marrow and solid organ transplant candidates and their donors
Reference Values:
Not applicable
Clinical References: 1. Terasaki PI, Bernoco F, Park MS, et al: Microdroplet testing for HLA-A, B,
C and D antigens. Am J Clin Path 1978 Feb;69(2):103-120 2. Colinas RJ, Bellisario R, Pass KA:
Multiplexed genotyping of beta-globin variants from PCR-amplified newborn blood spot DNA by
hybridization with allele-specific oligodeoxynucleotides coupled to an array of fluorescent microspheres.
Clin Chem 2000 Jul;46(7):996-998
HLA-B 1502 Genotype, Carbamazepine Hypersensitivity
Clinical Information: Clinical studies have demonstrated associations between some human
leukocyte antigen (HLA) genotypes and drug-induced adverse skin reactions. The presence of the
HLA-B*1502 allele increases the risk of developing toxic epidermal necrolysis (TEN) or Stevens-Johnson
syndrome (SJS), a milder form of TEN. The frequency of the HLA-B*1502 allele varies throughout Asia:
10% to 15% frequency in Chinese, 2% to 4% frequency in Southeast Asians, including Indians, and