Sorted By Test Name - Mayo Medical Laboratories

MSIO
88566
Reference Values:
0-12 years: < or =4.9 mg/L
13-18 years: < or =9.1 mg/L
>18 years: < or =13.2 mg/L
Clinical References: 1. Fink JN, Zacharisen MC: Hypersensitivity pneumonitis. In Allergy
Principles and Practice. Vol. 1. 5th edition. Edited by E Middleton Jr, CE Reed, EF Ellis, et al. St. Louis,
MO, Mosby-Year Book Inc., 1998 2. Anderson E, Jacob GL, Roberts GD, Homburger HA: Comparative
evaluation of enzyme immunoassay and immunodiffusion for detection of IgG antibodies to
hypersensitivity pneumonitis antigens. Poster Presentation, AAAAI Annual Meeting, San Diego, CA,
March 3-8, 2000. J Allergy Clin Immunol 2000;105:S304
Microsatellite Instability (MSI), Tumor
Clinical Information: Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch
syndrome, is an autosomal dominant inherited cancer syndrome that predisposes individuals to the
development of colorectal, endometrial, gastric, upper urinary tract, and other cancers. Individuals with
HNPCC/Lynch syndrome have a germline mutation in 1 of several genes involved in DNA mismatch
repair (MMR). The majority of mutations associated with HNPCC/Lynch syndrome occur in MLH1 and
MSH2; however mutations in MSH6 and PMS2 have also been identified. There are now several
strategies for evaluating individuals whose personal and/or family history of cancer is suggestive of
HNPCC/Lynch syndrome. Tumors from individuals with HNPCC/Lynch syndrome demonstrate
microsatellite instability (MSI), characterized by numerous alterations in a type of repetitive DNA called
microsatellites. Two distinct MSI tumor phenotypes have been described: MSI-H (instability in >30% of
microsatellites examined) and MSS/MSI-L (instability in