Sorted By Test Name - Mayo Medical Laboratories

9901
19988
Useful For: Identifying individuals previously diagnosed with rheumatoid arthritis who may be at
increased risk for developing more severe, erosive articular disease
Interpretation: In individuals with rheumatoid arthritis, the presence of the T allele, either as a C/T
heterozygote or as a T/T homozygote, suggests an increased risk for the development of more severe
articular disease. Individuals who are homozygous for the C allele (C/C) may have a less aggressive
disease course.
Reference Values:
An interpretive report will be provided.
Clinical References: 1. Firestein GS. Evolving concepts of rheumatoid arthritis. Nature 2003 May;
423(6937):356-361 2. Begovich AB, Carlton VE, Honigberg LE, et al: A missense single-nucleotide
polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid
arthritis. Am J Hum Genet 2004 Aug; 75(2): 330-337 3. Lie BA, Viken MK, Odegard S, et al:
Associations between the PTPN22 1858C-T polymorphism and radiographic joint destruction in patients
with rheumatoid arthritis: Results from a 10-year longitudinal study. Ann Rheum Dis. 2007 Dec;
66(12):1604-1609
Puchtler's Modification of Bennhold's Stain for Amyloid (Congo
Red)
Useful For: Histologic staining procedure for demonstrating amyloid.
Reference Values:
The laboratory will provide a pathology consultation and stained slide.
Pulmonary Cytology with FISH for the Detection of Lung Cancer
on Bronchial Brushing
Clinical Information: The National Cancer Institute estimates that more than 219,000 men and
women in the United States will be diagnosed with cancer of the lung and bronchus in 2009. The dismal
5-year survival of 15% for all patients diagnosed with lung cancer has been attributed to the fact that more
than 80% have advanced disease at the time of diagnosis. Cytologic analysis of brushing specimens
collected during bronchoscopy is widely used to help diagnose malignancy in patients suspected of having
lung cancer. Previous studies have shown that in centrally located tumors, the diagnostic sensitivity of
bronchial brushing cytology ranges from 23% to 93% (mean 61%).(1) However, the sensitivity is
considerably lower in peripheral tumors ranging from 15% to 84% (mean 54%), and even lower in those
patients with nodules