Sorted By Test Name - Mayo Medical Laboratories

FANGI
90429
FANG
90428
Interpretation: An elevation in the level of serum angiotensin converting enzyme (ACE), along with
radiographic evidence of infiltrates and/or adenopathy and organ biopsies showing noncaseating epithelial
granulomas is suggestive of a diagnosis of sarcoidosis. Serum ACE is significantly higher in most
(approximately 80%) patients with active sarcoidosis. ACE is also elevated in a number of other diseases
and in approximately 5% of the normal adult population.
Reference Values:
> or =18 years: 8-53 U/L
The reference interval for pediatric patients may be up to 50% higher than that of adults.
Clinical References: 1. Liebermann J: Elevation of serum angiotensin-converting-enzyme (ACE)
level in sarcoidosis. Am J Med 1975;59:365-372 2. Rodriguez GE, Shin BC, Abernathy RS, Kendig EL
Jr: Serum angiotensin-converting enzyme activity in normal children and in those with sarcoidosis. J
Pediatr 1981;99:68-72 3. Personal observations from a Mayo pediatric normal range study using a manual
method (Hana) 4. Maguire GA, Price CP: A continuous monitoring spectrophotometric method for the
measurement of angiotensin-converting enzyme in human serum. Ann Clin Biochem 1985;22:204-210
Angiotensin I, Plasma
Clinical Information: Angiotensin I is a ten amino acid peptide formed by Renin cleavage of
Angiotensinogen (Renin Substrate). Angiotensin I has little biological activity except that high levels can
stimulate Catecholamine production. It is metabolized to its biologically active byproduct Angiotensin II
by Angiotensin Converting Enzyme (ACE). The formation of Angiotensin I is controlled by negative
feedback of Angiotensin II and II on Renin release and by Aldosterone concentration. Levels of
Angiotensin I are increased in many types of hypertension. Angiotensin I levels are used to determine
Renin activity. Angiotensin I is excreted directly into the urine.
Reference Values:
Up to 25 pg/mL
This test was performed using a kit that has not been cleared or
approved by the FDA and is designated as research use only.
The analytic performance characteristics of this test have been
determined by Inter Science Institute. This test is not intended for
diagnosis or patient management decisions without confirmation
by other medically established means.
Test Performed by: Inter Science Institute
944 West Hyde Park Blvd.
Inglewood, CA 90302
Angiotensin II, Plasma
Clinical Information: Angiotensin II is a eight amino acid peptide formed by Angiotensin
Converting Enzyme (ACE) cleavage of Angiotensin I. Angiotensin II is metabolized further to
Angiotensin III. Angiotensin II release is controlled by Renin, blood pressure, blood volume, sodium
balance and by Aldosterone concentration. Levels of Angiotensin II are increased in many types of
hypertension. Angiotensin II stimulates the release of Anti-Diuretic Hormone, ACTH, Prolactin,
Luteinizing Hormone, Oxytocin and Aldosterone. Angiotensin II increases vasoconstriction and inhibits
tubular resorption of sodium, and can increase endothelial cell growth.
Reference Values:
10-60 pg/mL
This test was performed using a kit that has not been cleared or
approved by the FDA and is designated as research use only.
The analytic performance characteristics of this test have been
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