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IODU<br />

8639<br />

IOD<br />

81574<br />

ICRU<br />

60440<br />

Correlating total body iodine load with (131)I-uptake studies in assessing thyroid function<br />

Interpretation: Daily urinary output 1,000<br />

mcg/specimen may indicate dietary excess, but more frequently suggest recent drug or contrast media<br />

exposure.<br />

Reference Values:<br />

0-15 years: not established<br />

> or =16 years: 93-1,125 mcg/specimen<br />

Clinical References: 1. Knudsen N, Christiansen E, Brandt-Christensen M, et al: Age- and<br />

sex-adjusted iodine/creatinine ratio. A new standard in epidemiological surveys? Evaluation of three<br />

different estimates of iodine excretion based on casual urine samples and comparison to 24 h values. Eur J<br />

Clin Nutr 2000;54:361-363 2. Liberman CS, Pino SC, Fang SL, et al: Circulating iodine concentrations<br />

during and after pregnancy. J Clin Endocrinol Metab 1998;83:3545-3549<br />

Iodine, Random, Urine<br />

Clinical Information: Iodine is an essential element for thyroid hormone production. The<br />

measurement of urinary iodine serves as an index of adequate dietary iodine intake.<br />

Useful For: Monitoring iodine excretion rate as an index of daily iodine replacement therapy<br />

Correlating total body iodine load with (131)I uptake studies in assessing thyroid function<br />

Interpretation: Daily urinary output 1,000 mcg/L may<br />

indicate dietary excess, but more frequently suggest recent drug or contrast media exposure.<br />

Reference Values:<br />

0-15 years: not established<br />

> or =16 years: 26-705 mcg/L<br />

Clinical References: 1. Knudsen N, Christiansen E, Brandt-Christensen M, et al: Age- and<br />

sex-adjusted iodine/creatinine ratio. A new standard in epidemiological surveys? Evaluation of three<br />

different estimates of iodine excretion based on casual urine samples and comparison to 24 h values. Eur J<br />

Clin Nutr 2000;54:361-363 2. Liberman CS, Pino SC, Fang SL, et al: Circulating iodine concentrations<br />

during and after pregnancy. J Clin Endocrinol Metab 1998;83:3545-3549<br />

Iodine, Serum<br />

Clinical Information: Iodine is an essential element that is required for thyroid hormone production.<br />

The measurement of iodine serves as an index of adequate dietary iodine intake and iodine overload,<br />

particularly from iodine-containing drugs such as amiodarone.<br />

Useful For: Determination of iodine overload Monitoring iodine levels in individuals taking<br />

iodine-containing drugs<br />

Interpretation: Values between 80 ng/mL and 250 ng/mL have been reported to indicate<br />

hyperthyroidism. Values >250 ng/mL may indicate iodine overload.<br />

Reference Values:<br />

40-92 ng/mL<br />

Clinical References: Allain P, Berre S, Krari N, et al: Use of plasma iodine assay for diagnosing<br />

thyroid disorders. J Clin Pathol 1993 May;46(5):453-455<br />

Iodine/Creatinine Ratio, Random, Urine<br />

Clinical Information: Iodine is an essential element for thyroid hormone production. The<br />

Current as of January 4, 2013 7:15 pm CST 800-533-1710 or 507-266-5700 or <strong>Mayo</strong><strong>Medical</strong><strong>Laboratories</strong>.com Page 1046

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