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BARRP<br />

84440<br />

Regional lymphadenopathy, which follows, is the predominant clinical feature of CSD. Skin testing has<br />

been used in the past for CSD, but no skin test has been licensed for routine use. Trench fever, which was<br />

a problem during World War I and World War II, is characterized by a relapsing fever and severe pain in<br />

the shins. Interest in Bartonella quintana and Bartonella henselae has recently increased since its presence<br />

in AIDS patients and transplant patients has been documented. PH and febrile bacteremia syndrome are<br />

both syndromes that have afflicted patients with AIDS or those patients that are immunocompromised.<br />

While trench fever and CSD are usually self-limiting illnesses, the other Bartonella-associated diseases<br />

can be life-threatening.<br />

Useful For: Rapid diagnosis of Bartonella infection, especially in the context of a cat scratch or<br />

histopathology showing typical features of stellate microabscesses and/or positive Warthin-Starry stain<br />

Interpretation: A positive Immunoflourescence assay (IFA) IgM (titer >1:20) suggests a current<br />

infection with either Bartonella henselae or Barteonella quintana. A positive IgG (titer >1:128) suggests a<br />

current or previous infection. Increases in IgG titers in serial specimens would indicate an active infection.<br />

Normal serum specimens usually have an IgG titer of or = 1:256. IgM titers from normal serum were found to be or = 1:20 have not been<br />

seen in the normal population. Culture should also be considered, but this may not be an optimal method<br />

due to slow growth and fastidious nature of the organism.<br />

Reference Values:<br />

Bartonella henselae<br />

IgG:

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