Sorted By Test Name - Mayo Medical Laboratories

5581
SGUM
82483
Note: This test is not to be used to obtain a primary diagnosis. Primary testing should be performed by a
local pathology service; Mayo Clinic will render a second opinion, if requested.
Clinical References: Not applicable
Surgical Pathology Consultation, Slides or Blocks to Scottsdale
Clinical Information: The Mayo Department of Surgical Pathology is staffed by pathologists whose
special interests cover the entirety of surgical pathology. Because of the volume of specimens, ranging
from common to rare entities, the depth of experience is great. For many years, the Department of
Surgical Pathology has provided consultation service on difficult diagnostic problems. The histologic
specimens are usually sent by a referring pathologist to one of the surgical pathologists who is an expert
in the given area. Because this consultation service may not be widely known, it is being extended
through the auspices of Mayo Medical Laboratories. Slides received in Mayo Medical Laboratories are
reviewed by a surgical pathologist and, when necessary, sent to the pathologist whose area of special
interest encompasses the problem. Emphasis is placed on prompt replies. Of necessity, material can be
accepted only from pathologists. If the need for special studies is anticipated, appropriate tissue samplings
should be sent. Glutaraldehyde-fixed or, if necessary, formaldehyde-fixed wet tissue can be used for
electron microscopy. Paraffin blocks or unstained sections from paraffin blocks can be used for special
staining methods. In particular, a wide variety of diagnostically important antigens can be identified by
means of immunohistochemical procedures which are performed on paraffin sections. This service of
Mayo Medical Laboratories does not preclude sending material directly to a preferred surgical
pathologist, if the requesting pathologist is so accustomed.
Reference Values:
This request will be processed as a consultation. Appropriate stain(s) will be performed and charged
separately. An interpretation will be provided.
Sweet Gum, IgE
Clinical Information: Clinical manifestations of immediate hypersensitivity (allergic) diseases are
caused by the release of proinflammatory mediators (histamine, leukotrienes, and prostaglandins) from
immunoglobulin E (IgE)-sensitized effector cells (mast cells and basophils) when cell-bound IgE
antibodies interact with allergen. In vitro serum testing for IgE antibodies provides an indication of the
immune response to allergen(s) that may be associated with allergic disease. The allergens chosen for
testing often depend upon the age of the patient, history of allergen exposure, season of the year, and
clinical manifestations. In individuals predisposed to develop allergic disease(s), the sequence of
sensitization and clinical manifestations proceed as follows: eczema and respiratory disease (rhinitis and
bronchospasm) in infants and children less than 5 years due to food sensitivity (milk, egg, soy, and wheat
proteins) followed by respiratory disease (rhinitis and asthma) in older children and adults due to
sensitivity to inhalant allergens (dust mite, mold, and pollen inhalants).
Useful For: Testing for IgE antibodies may be useful to establish the diagnosis of an allergic disease
and to define the allergens responsible for eliciting signs and symptoms. Testing also may be useful to
identify allergens which may be responsible for allergic disease and/or anaphylactic episode, to confirm
sensitization to particular allergens prior to beginning immunotherapy, and to investigate the specificity of
allergic reactions to insect venom allergens, drugs, or chemical allergens.
Interpretation: Detection of IgE antibodies in serum (Class 1 or greater) indicates an increased
likelihood of allergic disease as opposed to other etiologies and defines the allergens that may be
responsible for eliciting signs and symptoms. The level of IgE antibodies in serum varies directly with the
concentration of IgE antibodies expressed as a class score or kU/L.
Reference Values:
Class IgE kU/L Interpretation
0 Negative
Current as of January 4, 2013 7:15 pm CST 800-533-1710 or 507-266-5700 or MayoMedicalLaboratories.com Page 1658