Sorted By Test Name - Mayo Medical Laboratories

FGLU
91649
GLT
82894
including autoimmune thyroid disease (eg, thyrotoxicosis, Graves' disease, Hashimoto's thyroiditis,
hypothyroidism), pernicious anemia, premature ovarian failure, Addison's disease (idiopathic
adrenocortical failure), and vitiligo. GAD65 antibodies are found in the serum of approximately 8% of
healthy subjects older than age 50, usually in low titer, but often accompanied by related "thyrogastric"
autoantibodies.
Useful For: Possible use in evaluating patients with stiff-man syndrome, autoimmune cerebellitis and
other acquired central nervous system disorders affecting gabaminergic neurotransmission. Clinical utility
remains to be determined.
Interpretation: Intrathecal synthesis of GAD65 antibody has been demonstrated in patients with
stiff-man syndrome, but cerebrospinal fluid (CSF) values are log orders lower than serum. We have not
determined the frequency of GAD65 antibodies in CSF of patients with various diagnoses.
Reference Values:
< or =0.02 nmol/L
Clinical References: 1. Saiz A, Arpa J, Sagasta A, et al: Autoantibodies to glutamic acid
decarboxylase in three patients with cerebellar ataxia, late-onset insulin-dependent diabetes mellitus and
polyendocrine autoimmunity. Neurology 1997 October;49(4):1026-1030 2. Boylan KB, Lennon VA:
Cerebellar ataxia with glutamic acid decarboxylase antibody. Ann Neurol 1999;46:457 (abstract) 3.
Dalakas MC, Li M, Fujii M, Jacobowitz DM: Stiff person syndrome: quantification, specificity, and
intrathecal synthesis of GAD65 antibodies. Neurology 2001 September 11;57:780-784
Gluten IgG
Reference Values: