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circulating T-cell counts have been shown to be negatively correlated with plasma cortisol
concentration.(2-4) In fact, cortisol and catecholamine concentrations control distribution and, therefore,
numbers of naive versus effector CD4 and CD8 T cells.(2) It is generally accepted that lower CD4 T-cell
counts are seen in the morning compared with the evening (5), and during summer compared to winter.(6)
These data, therefore, indicate that timing and consistency in timing of blood collection is critical when
serially monitoring patients for lymphocyte subsets.
Useful For: Natural Killer (NK) Cytotoxicity Profile: Assessment of patients with several different
immunodeficiency diseases in which the NK cell activity has been reported to be diminished or absent.
These diseases include: -Reticular dysgenesis -X-linked severe combined immunodeficiency disease
(SCID) caused by mutation of the interleukin (IL)-2 receptor gamma chain -Autosomal recessive SCID
caused by JAK3 mutations, and caused by RAG-1 and RAG-2 mutations (Omenn syndrome) -Adenosine
deaminase deficiency -Purine nucleoside phosphorylase deficiency -Zeta-associated protein-70 (ZAP-70)
tyrosine kinase deficiency -Chediak-Higashi syndrome T- and B-Cell Quantitation by Flow Cytometry:
Monitoring CD4 counts and assessing immune deficiencies
Interpretation: Unmeasurable lytic activity or activity or =18 years: 52-84%
% B Cells (CD19)
0-2 months: 6-32%*
3-5 months: 11-41%*
6-11 months: 14-37%*
12-23 months: 16-35%*
2-5 years: 14-33%*
6-11 years: 13-27%*
12-17 years: 6-23%*
> or =18 years: 5-25%
% Natural Killer (CD16+CD56)
0-2 months: 4-18%*
3-5 months: 3-14%*
6-23 months: 3-15%*
2-11 years: 4-17%*
12-17 years: 3-22%*
> or =18 years: 5-30%
% Helper Cells (CD4)
0-2 months: 35-64%*
3-5 months: 35-56%*
Current as of January 4, 2013 7:15 pm CST 800-533-1710 or 507-266-5700 or MayoMedicalLaboratories.com Page 1285