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FSTRP<br />

90440<br />

FSTSC<br />

91984<br />

STR<br />

8746<br />

J Infect Dis 1995;171:885-889 4. Butler JC, Hoffman J, Cetron MS, et al: The continued emergence of<br />

drug-resistant Streptococcus pneumoniae in the United States. An update from the Centers for Disease<br />

Control and Prevention's Pneumococcal Sentinel Surveillance System. J Infect Dis 1996;174:986-993 5.<br />

Jacob GL, Homburger HA: Simultaneous Quantitative Measurement of IgG Antibodies to Streptococcus<br />

Pneumoniae Serotypes by Microsphere Photometry. J Allergy Clin Immunol,2004;113(2) Suppl (Abstract<br />

1049, pS288) 6.Table 2: Geometric mean concentrations (ug/mL) of pneumococcal antibodies following<br />

the third and fourth doses of Prevnar or control when administered concurrently with DTP-HbOC in the<br />

efficacy study. In Physician's Desk Reference 2003. 57th edition. Montvale, NJ, Thompson PDR, p 3455<br />

7. Plikaytis BD, Holder PF, Pais LB, et al: Determination of parallelism and nonparallelism in bioassay<br />

dilution curves. J Clin Microbiology 1994 October;32:2441-2447 8. Plikaytis BD, Goldblatt D, Frasch<br />

CE, et al: An analytical model applied to a multicenter pneumococcal enzyme-linked immunosorbent<br />

assay study. J Clin Microbiology 2000 June;38(6):2043-2050<br />

Streptomycin, HPLC<br />

Reference Values:<br />

Drug concentrations are expressed in mcg/mL.<br />

Following intramuscular injection of 1 g of streptomycin as the<br />

sulfate, a peak serum level of 25 to 50 mcg/mL is reached within<br />

1 hour.<br />

<strong>Test</strong> Performed by: Focus Diagnostics, Inc.<br />

5785 Corporate Avenue<br />

Cypress, CA 90630-4750<br />

Streptozyme Screen with Reflex to Titer<br />

Reference Values:<br />

Negative<br />

<strong>Test</strong> Performed by: Focus Diagnostics, Inc.<br />

5785 Corporate Ave.<br />

Cypress, CA 90630-4750<br />

Striational (Striated Muscle) Antibodies, Serum<br />

Clinical Information: Autoantibodies directed against the contractile elements of striated muscle are<br />

found in 30% of adult patients with myasthenia gravis and in 80% of those with thymoma. These<br />

antibodies may also be detected in patients with: Lambert-Eaton myasthenic syndrome, small-cell lung<br />

carcinoma, breast carcinoma, patients treated with D-penicillamine, bone marrow transplant recipients<br />

having graft-versus-host disease, and autoimmune liver disorders.<br />

Useful For: This test is a useful serological aid in the diagnosis of thymoma, especially in patients with<br />

onset of myasthenia gravis (MG) younger than 45 years. It is more predictive of thymoma when<br />

accompanied by a muscle acetylcholine receptor (AChR) modulating antibody value of > or =90% AChR<br />

loss and is most predictive of thymoma when accompanied by CRMP-5-IgG. It is useful as a screening<br />

test for MG in older patients, especially when tests for muscle AChR antibodies are negative. Serial<br />

measurements are useful in monitoring the efficacy of immunosuppressant treatment in patients with MG.<br />

Serial measurements are useful after treatment of thymoma. Measurements of muscle AChR binding,<br />

muscle AChR modulating antibody, and CRMP-5-IgG (if initially positive) are also recommended. Serial<br />

measurements in recipients of D-penicillamine or bone marrow allografts may be useful in monitoring<br />

autoimmune complications and graft-versus-host disease, respectively.<br />

Interpretation: Autoantibodies reactive with contractile elements of skeletal muscle are detectable in<br />

Current as of January 4, 2013 7:15 pm CST 800-533-1710 or 507-266-5700 or <strong>Mayo</strong><strong>Medical</strong><strong>Laboratories</strong>.com Page 1634

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