Sorted By Test Name - Mayo Medical Laboratories

CD4NY
28334
2-5 years: 490-1,300 cells/mcL*
6-11 years: 370-1,100 cells/mcL*
12-17 years: 330-920 cells/mcL*
18-55 years: 169-955 cells/mcL
>55 years: 101-839 cells/mcL
LYMPHOCYTE RATIO
H/S ratio: > or =1.0
*Shearer WT, Rosenblatt HM, Gelman RS, et al: Lymphocyte subsets in healthy children from birth
through 18 years of age: The Pediatric AIDS Clinical Trials Group P1009 study. J Allergy Clin Immunol
2003;112(5):973-980
Clinical References: 1. Mandy FF, Nicholson JK, McDougal JS: CDC: Guidelines for performing
single-platform absolute CD4+ T-cell determinations with CD45 gating for persons infected with human
immunodeficiency virus. Center for Disease Control and Prevention. MMWR Morb Mortal Wkly Rep
2003;52:1-13 2. Carmichael KF, Abayomi A: Analysis of diurnal variation of lymphocyte subsets in
healthy subjects and its implication in HIV monitoring and treatment. 15th Intl Conference on AIDS,
Bangkok, Thailand, 2004, Abstract B11052 3. Dimitrov S, Benedict C, Heutling D, et al: Cortisol and
epinephrine control opposing circadian rhythms in T-cell subsets. Blood 2009;113(21):5134-5143 4.
Dimitrov S, Lange T, Nohroudi K, Born J: Number and function of circulating antigen presenting cells
regulated by sleep. Sleep 2007;30:401-411 5. Kronfol Z, Nair M, Zhang Q, et al: Circadian immune
measures in healthy volunteers: relationship to hypothalamic-pituitary-adrenal axis hormones and
sympathetic neurotransmitters. Psychosom Med 1997;59:42-50 6. Malone JL, Simms TE, Gray GC, et al:
Sources of variability in repeated T-helper lymphocyte counts from HIV 1-infected patients: total
lymphocyte count fluctuations and diurnal cycle are important. J AIDS 1990;3:144-151 7. Paglieroni TG,
Holland PV: Circannual variation in lymphocyte subsets, revisited. Transfusion 1994;34:512-516 8. U.S.
Department of Health and Human Services: Recommendations for prophylaxis against Pneumocystis
carinii pneumonia for adults and adolescents infected with human immunodeficiency virus. MMWR
Morb Mortal Wkly Rep 1994;43:1-21 9. Shearer WT, Rosenblatt HM, Gelman RS, et al: Lymphocyte
subsets in healthy children from birth through 18 years of age: The Pediatric AIDS Clinical Trials Group
P1009 study. J Allergy Clin Immunol 2003 November;112(5):973-980
CD4 Count for Monitoring, New York, Blood
Clinical Information: The infection of and subsequent decrease in the number of T-cells expressing
the CD4 receptor (T-helper cells) is the main pathogenic mechanism of HIV. Progressive depletion of
CD4 T-cells is associated with an increased likelihood of AIDS and an unfavorable prognosis. The US
Public Health Service recommends that CD4 levels be monitored every 3 to 6 months in all HIV-infected
persons.(1)
Useful For: Monitoring CD4 levels in HIV-infected patients
Interpretation: When the CD4 count falls below 500 cells/mcL, HIV-positive patients can be
diagnosed with AIDS and can receive antiretroviral therapy. When the CD4 count falls below 200
cells/mcL, prophylaxis against Pneumocystis jiroveci (formerly carinii) pneumonia is recommended.
Reference Values:
T & B SURFACE MARKER
% T cells (CD3)
0-2 months: 53-84%*
3-5 months: 51-77%*
6-11 months: 49-76%*
12-23 months: 53-75%*
2-5 years: 56-75%*
6-11 years: 60-76%*
12-17 years: 56-84%*
18-55 years: 59-83%
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