Sorted By Test Name - Mayo Medical Laboratories

FALAU
57350
ALADW
to secondary inhibition of ALA dehydratase. Among the secondary causes, acute lead intoxication causes
the highest degree of aminolevulinic aciduria. Less significant elevations include chronic lead
intoxication, tyrosinemia type I, alcoholism, and pregnancy. For additional information on the
recommended order of testing, see Porphyria (Acute) Testing Algorithm and Porphyria (Cutaneous)
Testing Algorithm in Special Instructions.
Useful For: Assistance in the differential diagnosis of the various porphyrias An indicator of lead
intoxication in children
Interpretation: Elevated values are found in several inherited and acquired conditions that are
characterized by various degrees of aminolevulinic aciduria: -Aminolevulinic acid dehydratase deficiency
porphyria -Acute intermittent porphyria -Hereditary coproporphyria -Variegate porphyria -Intoxication
with lead and other heavy metals -Tyrosinemia type I -Alcoholism and alcohol induced hepatitis
-Pregnancy
Reference Values:
or =18 years: < or =15 nmol/mL
Clinical References: 1. Meyer UA, Schuurmans MM, Lindberg RL: Acute porphyrias: pathogenesis
of neurological manifestations. Semin Liver Dis 1998;18:43-52 2. Warren MJ, Cooper JB, Wood SP,
Shoolingin-Jordan PM: Lead poisoning, haem synthesis and 5-aminolaevulinic acid dehydratase. Trends
Biochem Sci 1998;23:217-221 3. Anderson KE, Sassa S, Bishop DF, et al: Disorders of heme
biosynthesis: X-linked sideroblastic anemia and the porphyrias. In The Metabolic Basis of Inherited
Disease. 8th edition. Edited by CR Scriver, AL Beaudet, WS Sly, et al. New York, McGraw-Hill Medical
Publishing Division, 2001, pp 2991-3062 4. Nuttall KL, Klee GG: Analytes of Hemoglobin
Metabolism-Porphyrins, Iron, and Bilirubin. In Tietz Textbook of Clinical Chemistry. Fifth edition.
Edited by CA Burtis, ER Ashwood. Philadelphia, WB Saunders Company, 2001, pp 584-607
Aminolevulinic Acid (ALA), Urine
Reference Values:
Procedure Units Ref Interval
Creatinine, Urine – mg/dL mg/dL
Creatinine, Urine-mg/day mg/d
Age Male Female
3 – 8 years 140-700 140-700
9-12 years 300-1300 300-1300
13-17 years 500-2300 400-1600
18-50 years 1000-2500 700-1600
51-80 years 800-2100 500-1400
81 years and older 600-2000 400-1300
Aminolevulinic Acid umol/L umol/L 0-35
Aminolevulinic Acid umol/day umol/d 0-60 Test Performed By: ARUP
Laboratories 500 Chipeta Way Salt
Lake City, UT 84108
Aminolevulinic Acid Dehydratase (ALA-D), Washed
31895
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