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26-55 years: 6.4-41.7%<br />

56-70 years: 6.4-27.7%<br />

Reference values have not been established for patients that are 70 years of age.<br />

CD4 RTE Absolute<br />

Males<br />

1 month-17 years: 50.0-926.0 cells/mcL<br />

18-70 years: 42.0-399.0 cells/mcL<br />

Females<br />

1 month-17 years: 170.0-1,007.0 cells/mcL<br />

18-70 years: 42.0-832.0 cells/mcL<br />

Reference values have not been established for patients that are 70 years of age.<br />

CD8 T-CELL RTE<br />

CD8 Absolute<br />

1 month-17 years: 143-902 cells/mcL<br />

18-35 years: 208-938 cells/mcL<br />

36-55 years: 142-844 cells/mcL<br />

56-70 years: 58-680 cells/mcL<br />

Reference values have not been established for patients that are 70 years of age.<br />

CD8 RTE %<br />

1 month-17 years: 0.1-1.7%<br />

18-45 years: 0.0-0.6%<br />

>46-70 years: 0.0-0.3%<br />

Reference values have not been established for patients that are 70 years of age.<br />

CD8 RTE Absolute<br />

1 month-17 years: 0.2-4.3 cells/mcL<br />

18-25 years: 0.0-3.4 cells/mcL<br />

26-50 years: 0.0-2.5 cells/mcL<br />

51-70 years: 0.0-0.7 cells/mcL<br />

Reference values have not been established for patients that are 70 years of age.<br />

Clinical References: 1. Douek DC, McFarland RD, Keiser PH, et al: Changes in thymic function<br />

with age and during the treatment of HIV infection. Nature 1998;396:690-694 2. Hazenberg MD,<br />

Verschuren MC, Hamann D, et al: T cell receptor excision circles as markers for recent thymic emigrants:<br />

basic aspects, technical approach, and guidelines for interpretation. J Mol Med 2001;79:631-640 3.<br />

Hassan J, Reen DJ: Human recent thymic emigrants-identification, expansion, and survival<br />

characteristics. J Immunol 2001;167:1970-1976 4. Kimmig S, Przybylski GK, Schmidt CA, et al: Two<br />

subsets of naïve T-helper cells with distinct T-cell receptor excision circle content in human adult<br />

peripheral blood. J Exp Med 2002;195(6):789-794 5. McFarland RD, Douek DC, Koup RA, et al:<br />

Identification of human recent thymic emigrant phenotype. Proc Natl Acad Sci 2000;97(8):4215-4220 6.<br />

Junge S, Kloeckener-Gruissem B, Zufferey R, et al: Correlation between recent thymic emigrants and<br />

CD31+ (PECAM-1) CD4 T-cells in normal individuals during aging and in lymphopenic children. Eur J<br />

Immunol 2007;37:3270-3280 7. Dong X, Hoeltzle MV, Abraham RS: Evaluation of CD4 and CD8 recent<br />

thymic emigrants in healthy adults and children. Unpublished data 2008 8. Duszczyszyn DA, Beck JD,<br />

Antel J, et al: Altered naive CD4 and CD8 T-cell homeostasis in patients with relapsing-remitting<br />

multiple sclerosis: thymic versus peripheral (non-thymic) mechanisms. Clin Exp Immunol<br />

2005;143:305-313<br />

Current as of January 4, 2013 7:15 pm CST 800-533-1710 or 507-266-5700 or <strong>Mayo</strong><strong>Medical</strong><strong>Laboratories</strong>.com Page 1741

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