Sorted By Test Name - Mayo Medical Laboratories

FCHO
91157
CHLBF
82945
Reference Values:
Up to 80 pg/mL
This test was developed and its performance characteristics
determined by Inter Science Institute. It has not been cleared or
approved by the US Food and Drug Administration. The FDA has
determined that such clearance or approval is not necessary.
Test Performed by: Inter Science Institute
944 West Hyde Park Blvd.
Inglewood, CA 90302
Cholestanol
Reference Values:
0-8 weeks: 0.89 - 5.18 ug/mL (n=38)
>8 weeks: 0.86 - 3.71 ug/mL (n=68)
Test Performed By: Kennedy Krieger Institute
707 North Broadway
Baltimore, MD 21205
Clinical References: Kelley RI. Diagnosis of Smith-Lemli-Opitz syndrome by gas
chromatography/mass spectrometry of 7-dehydrocholesterol in plasma, amniotic fluid, and cultured skin
fibroblasts. Clin Chim Acta 1995; 236:45-58
Cholesterol, BF
Clinical Information: Pleural Fluid: Quantitation of cholesterol in body fluids is clinically important
and relevant in particular to the diagnosis of a cholesterol effusion. Cholesterol effusions (also known as
pseudochylothorax or chyliform effusion) are important to differentiate from chylothorax, as their
etiologies and therapeutic management strategies differ. Pseudochylous or chyliform effusions accumulate
gradually through the breakdown of cellular lipids in long-standing effusions such as rheumatoid pleuritis,
tuberculosis, or myxedema and by definition the effluent contains high concentrations of cholesterol. The
fluid may have a milky or opalescent appearance and be similar to that of a chylous effusion, which
contains high concentrations of triglycerides in the form of chylomicrons. An elevated cholesterol >250
mg/dL defines a cholesterol effusion in pleural fluid. Peritoneal Fluid: Ascites is the pathologic
accumulation of excess fluid in the peritoneal cavity. Cholesterol analysis in peritoneal fluid may be a
useful index to separate malignant ascites (>45-48 mg/dL) from cirrhotic ascites. Using a cutoff value of
48 mg/dL, the sensitivity, specificity, positive and negative predictive value, and overall diagnostic
accuracy for differentiating malignant from nonmalignant ascites were reported as 96.5%, 96.6%, 93.3%,
98.3%, and 96.6%, respectively.(1) Synovial Fluid: Normal synovial fluid contains extremely low
concentrations of lipids. Abnormalities in synovial fluid lipids may be attributed to cholesterol-rich
pseudochylous effusions which may be associated with chronic rheumatoid arthritis, lipid droplets due to
traumatic injury and rarely due to severe chylous effusions associated with systemic lupus erythematosus,
filariasis, pancreatitis, and trauma.(1) However, these diseases can usually be differentiated clinically and
by gross and microscopic examination; quantification of lipids in synovial fluid only provides supporting
information to the clinical picture.
Useful For: Distinguishing between chylous and nonchylous effusions Identifying iatrogenic effusions
Interpretation: Not applicable.
Reference Values:
Not applicable
Clinical References: 1. McPherson RA, Matthew RP, Henry JB: Cerebrospinal, Synovial, and
Current as of January 4, 2013 7:15 pm CST 800-533-1710 or 507-266-5700 or MayoMedicalLaboratories.com Page 451