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BUTAS<br />

8427<br />

CPR<br />

8804<br />

acute nonlymphocytic leukemia after treatment with busulfan and cyclophosphamide. N Engl J Med 1983<br />

December 1;309(22):1347-1353 2. Slattery JT, Sanders JE, Buckner CD, et al: Graft-rejection and toxicity<br />

following bone marrow transplantation in relation to busulfan pharmacokinetics. Bone Marrow Transpl<br />

1995 July;16(1):31-42 3. Slattery JT, Risler LJ: Therapeutic monitoring of busulfan in hematopoietic stem<br />

cell transplantation. Ther Drug Monit 1998 October;20(5):543-549 4. Czerwinski M, Gibbs M, Slattery<br />

JT: Busulfan conjugation by glutathione S-transferases alpha, mu, and pi. Drug Metab Dispos 1996<br />

September;24(9):1015-1019<br />

Butalbital, Serum<br />

Clinical Information: Butalbital is a short-acting barbiturate with hypnotic properties that is used in<br />

combination with other drugs such as acetaminophen, salicylate, caffeine, and codeine.(1) Butalbital is<br />

administered orally. The duration of its hypnotic effect is about 3 to 4 hours. The drug distributes<br />

throughout the body, with a volume of distribution (Vd) of 0.8 L/kg, and about 26% of a dose is bound to<br />

plasma proteins. Butalbital's half-life is about 35 to 88 hours. Excretion occurs mainly in the urine.(1,2)<br />

Useful For: Monitoring butalbital therapy<br />

Interpretation: Butalbital level > or =10 mcg/mL is toxic<br />

Reference Values:<br />

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