Sorted By Test Name - Mayo Medical Laboratories

CFRC
89653
EPRP
60235
result in intermittent bacteremia. A hallmark feature of subacute bacterial endocarditis is a continuous
bacteremia. The sources of bacteremia are the genitourinary tract (25%), the respiratory tract (20%),
abscesses (10%), surgical wounds (5%), the biliary tract (5%), other known sites (10%), and unknown
sites (25%).
Reference Values:
No growth
Identification of all organisms
Clinical References: Mandell GL, Bennett JE, Dolin R: In Mandell, Douglas, and Bennett's
Principles and Practice of Infectious Diseases. Sixth edition. New York, NY, Churchill Livingstone, 2005,
pp. 906-926.
Bacterial Culture, Cystic Fibrosis, Respiratory
Clinical Information: Life expectancy of patients with cystic fibrosis (CF) has increased steadily
over the past 50 years, in large part due to improvements in the management of lung disease in this patient
population. Still, chronic lung infection is responsible for 75% to 85% of deaths in patients with CF.
Appropriate treatment for the causative organism can reduce morbidity and mortality. The number of
microbial species associated with CF lung disease is relatively limited. These include Pseudomonas
aeruginosa (mucoid and nonmucoid), Staphylococcus aureus, Burkholderia cepacia complex,
Stenotrophomonas maltophilia, other nonfermenting gram-negative rods, Haemophilus influenzae, and
Streptococcus pneumoniae. Nontuberculous mycobacteria and Aspergillus species may also play a role in
CF lung disease, in addition to common respiratory viruses. This culture, which is specifically designed
for CF patients, utilizes conventional and additional selective media (compared to non-CF respiratory
cultures) to isolate bacteria commonly associated with pulmonary disease in CF patients. In selected
centers, lung transplantation is performed on CF patients. This test is appropriate for lung transplant
patients with underlying CF because they can continue to harbor the same types of organisms as they did
pretransplantation. CF patients may be colonized or chronically infected by these organisms over a long
period of time.
Useful For: Detection of aerobic bacterial pathogens from cystic fibrosis patient specimens
Interpretation: A negative test result is no growth of bacteria or growth of only usual flora. A negative
result does not rule out all causes of infectious lung disease (see "Cautions"). For positive test results,
pathogenic bacteria are identified. Because cystic fibrosis (CF) patients may be colonized or chronically
infected by some organisms over a long period of time, positive results must be interpreted in conjunction
with previous findings and the clinical picture to appropriately evaluate results.
Reference Values:
No growth or usual flora
Clinical References: Infections of the lower respiratory tract. In Bailey & Scott's Diagnostic
Microbiology. 12th edition. Edited by B Forbes, D Sahm, A Weissfeld. St. Louis, Mosby Elsevier, 2002
pp 798-813
Bacterial Enteric Pathogens, Molecular Detection, PCR
Clinical Information: Despite advances in water treatment, food safety, and sanitary conditions,
acute diarrheal disease remains a leading cause of morbidity and mortality worldwide. Most bacterial
enteric infections in the United States originate within the food supply chain. According to the CDC, 43%
of laboratory-confirmed bacterial enteric infections in the US are caused by Salmonella species, followed
by Campylobacter species (33%), Shigella species (17%), shiga toxin-producing Escherichia coli (4.1%),
and Yersinia species (0.9%).(1) Although Salmonella, Campylobacter, Shigella, Yersinia species, and
Escherichia coli O157:H7 are easily cultivated on standard selective and differential bacteriologic media,
isolation and final identification are time consuming, delaying diagnosis for several days and putting
patients at risk for untreated infection and spread of infection to others. For example, the time to final
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