Sorted By Test Name - Mayo Medical Laboratories

SALC
8480
SALM
82754
Salicylate, Serum
1001 NW Technology Dr.
Lee's Summit, MO 64086
Clinical Information: Therapeutic salicylates include, among others, salicylic acid, sodium
salicylate, methyl salicylate (oil of wintergreen), and acetylsalicylic acid (aspirin). Aspirin is an analgesic,
antipyretic, anti-inflammatory drug contained in a large number of preparations. Aspirin is rapidly
hydrolyzed by hepatic and blood esterases to the pharmacologically active intermediate, salicylic acid,
which has a dose-dependent serum half-life ranging from 3 to 20 hours. Stimulation of the respiratory
center in the central nervous system and uncoupling of oxidative phosphorylation are direct effects of
salicylate that lead to many of the toxic symptoms observed in overdose situations. Symptoms of
salicylate toxicity can include nausea, vomiting, tinnitus, headache, hyperpnea, confusion, hyperthermia,
slurred speech, and convulsions. Acid-base disturbances such as compensated respiratory alkalosis (mild
toxicity) and metabolic acidosis with increased anion gap (severe toxicity) are commonplace.
Useful For: Assessing toxicity This test is NOT useful for assessing low-dose aspirin therapy
Interpretation: Adult therapeutic concentration: 2 mg/dL to 20 mg/dL Toxic concentration: > or =50
mg/dL
Reference Values:
Adult therapeutic concentration: 2-20 mg/dL
Toxic concentration: > or =50 mg/dL
Clinical References: 1. Done AK: Aspirin overdosage: incidence, diagnosis, and management.
Pediatrics 1978;62:890-897 2. Medical Toxicology, 3rd edition, RC Dart editor. 2004 p 1811
Salmon, IgE
Clinical Information: Clinical manifestations of immediate hypersensitivity (allergic) diseases are
caused by the release of proinflammatory mediators (histamine, leukotrienes, and prostaglandins) from
immunoglobulin E (IgE)-sensitized effector cells (mast cells and basophils) when cell-bound IgE
antibodies interact with allergen. In vitro serum testing for IgE antibodies provides an indication of the
immune response to allergen(s) that may be associated with allergic disease. The allergens chosen for
testing often depend upon the age of the patient, history of allergen exposure, season of the year, and
clinical manifestations. In individuals predisposed to develop allergic disease(s), the sequence of
sensitization and clinical manifestations proceed as follows: eczema and respiratory disease (rhinitis and
bronchospasm) in infants and children less than 5 years due to food sensitivity (milk, egg, soy, and wheat
proteins) followed by respiratory disease (rhinitis and asthma) in older children and adults due to
sensitivity to inhalant allergens (dust mite, mold, and pollen inhalants).
Useful For: Testing for IgE antibodies may be useful to establish the diagnosis of an allergic disease
and to define the allergens responsible for eliciting signs and symptoms. Testing also may be useful to
identify allergens which may be responsible for allergic disease and/or anaphylactic episode, to confirm
sensitization to particular allergens prior to beginning immunotherapy, and to investigate the specificity of
allergic reactions to insect venom allergens, drugs, or chemical allergens.
Interpretation: Detection of IgE antibodies in serum (Class 1 or greater) indicates an increased
likelihood of allergic disease as opposed to other etiologies and defines the allergens that may be
responsible for eliciting signs and symptoms. The level of IgE antibodies in serum varies directly with the
concentration of IgE antibodies expressed as a class score or kU/L.
Reference Values:
Class IgE kU/L Interpretation
0 Negative
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