Sorted By Test Name - Mayo Medical Laboratories

FNEUR
90156
FNEU
91688
Aksamit AJ, Preissner CM, Homburger HA: Quantitation of 14-3-3 and neuron-specific enolase proteins
in CSF in Creutzfeldt-Jacob disease. Neurology 2001;57:728-730 4. Riley RD, Heney D, Jones DR, et al:
A systematic review of molecular and biological tumor markers in neuroblastoma. Clin Cancer Res
2004;10:4-12 5. Portela-Gomes GM, Hacker GW, Weitgasser R: Neuroendocrine cell markers for
pancreatic islets and tumors. Appl Immunohistochem Mol Morphol 2004;12:183-192 6. Wijdicks EF,
Hijdra A, Young GB, et al: Practive parameter: prediction of outcome in comatose survivors after
cardiopulmonary resuscitation (an evidence-based review). Neurology 2006;67:203-210
Neurotensin
Clinical Information: Neurotensin is a 13 amino acid peptide produced primarily by endocrine cells
of the ileal mucosa. Physiological actions of Neurotensin include hypertension, vasodilation,
hyperglycemia, and inhibition of gastric motility. Its C-terminus is similar to Angiotensin I. It is a potent
analgesic affecting hypothermia, muscle relaxation, and decreased motor activity. Pancreatic Polypeptide
secretion is strongly stimulated by Neurotensin. Neurotensin appears to cause the release of Luteinizing
Hormone-Releasing Hormone and Corticotropin Releasing Hormone effecting the release of Luteinizing
Hormone, Follicle Stimulating Hormone, and ACTH but not Thyroid Stimulating Hormone or Growth
Hormone. Neurotensin also stimulates pancreatic bicarbonate and intestinal secretion. Neurotensin levels
are stimulated by food and Bombesin. Elevated levels have been found in pancreatic endocrine tumors,
Oat Cell, Squamous, and Adeno Carcinomas. Elevated levels have been found to cause watery diarrhea.
Reference Values:
50-100 pg/mL
Test Performed By: Inter Science Inst
944 West Hyde Park
Inglewood, CA 90302
Neurotransmitter Metabolites/Amines
Interpretation: Recently, a cerebral folate deficiency syndrome has been described. The clinical
picture is one of developmental delay/regression, cerebellar ataxia, with or without seizures, with or
without autism. This disorder is treatable with folinic acid. If your patient fits the clinical picture we can
measure 5- methyltetrahydrofolate in the CSF we already have if you wish to add on this test. Please see:
Ramaekers VT, Blau N. Cerebral folate deficiency, Dev Med Child Neurol. 2004 Dec;46(12):843-51.
Cerebral folate deficiency has also been described in mitochondrial disorders. We now have biomarkers
for folinic acid/pyridoxine responsive seizures (Antiquitin, ALDH7A1) that appear on our
neurotransmitter metabolite chromatogram.
Reference Values:
Age 5HIAA HVA 3-O-MD
(years) (nmol/L) (nmol/L) (nmol/L)
0-0.2 208-1159 337-1299