Sorted By Test Name - Mayo Medical Laboratories

PPFE
8739
Noncomplexed (free) protoporphyrin is increased disproportionately in erythrocytes in cases of
erythropoietic protoporphyria. The following algorithms are available in Special Instructions: -Porphyria
(Acute) Testing Algorithm -Porphyria (Cutaneous) Testing Algorithm
Useful For: Establishing a biochemical diagnosis of erythropoietic protoporphyria Differential
diagnosis of chronic intoxication from exposure to a variety of causes including heavy metals and
chemicals Differential diagnosis in some cases of iron-deficiency anemia There are 2 test options: whole
blood (PPFE/8739 Protoporphyrins, Fractionation, Whole Blood) and washed RBCs (PPFWE/31891
Protoporphyrins, Fractionation, Washed Erythrocytes). The whole blood option is easiest for clients but
requires that the specimen arrive at Mayo Medical Laboratories within 72 hours of draw. When this
cannot be ensured, washed RBCs should be submitted.
Interpretation: Values of zinc-complexed protoporphyrin >60 mcg/dL suggest iron deficiency anemia
or may indicate chronic intoxication by heavy metals or organic chemicals. A predominance of
noncomplexed (free) protoporphyrin indicates a diagnosis of erythropoietic protoporphyria.
Reference Values:
FREE PROTOPORPHYRIN