Sorted By Test Name - Mayo Medical Laboratories

YMICR
82992
FYSTG
92000
0-16 years: depends on dose given
Xylose excretion, % dose 5 hr:
0-16 years: 16-40 %
Test Performed By: ARUP Laboratories
500 Chipeta Way
Salt Lake City, UT 84108
Y Chromosome Microdeletions, Molecular Detection
Clinical Information: Yq microdeletions involving some or all of the azoospermic factor (AZF)
region are the most frequently identified cause of spermatogenic failure in chromosomally normal men
with nonobstructive azoospermia (3%-15%) or severe oligospermia (6%-10%). Among unselected
infertile males, the overall frequency of Yq microdeletions is approximately 3%. The relative frequency
of Yq microdeletions makes the evaluation for them an important aspect of the diagnostic work up in
infertile males, especially those with azoospermia or severe oligospermia. Most cases of Yq
microdeletions occur de novo, and due to the consequential infertile phenotype, they are typically not
transmitted. However, in cases where assisted reproductive technology (example: TESE followed by
ICSI) is used to achieve viable pregnancy, all male offspring born to a microdeletion carrier will carry the
deletion and may be infertile. Men testing positive for 1 or more microdeletions who are enrolled in an in
vitro fertilization treatment program may wish to consider alternative options to intracytoplasmic sperm
injection (eg, donor sperm) and consultation with an experienced reproductive endocrinologist and
medical geneticist is recommended. Most Y microdeletions are the result of homologous recombination
between repeated sequence blocks. Testing for deletions involves investigating for the presence or
absence of markers located within non-polymorphic regions of the AZF region.
Useful For: Evaluating men with azoospermia, severe oligozoospermia, or otherwise unexplained male
factor infertility
Interpretation: An interpretive report will be provided.
Reference Values:
An interpretive report will be provided.
Clinical References: 1. Stahl PJ, Masson P, Mielnik A, et al: A decade of experience emphasizes
that testing for Y microdeletions is essential in American men with azoospermia and severe
oligozoospermia. Fertil Steril 2009 Nov 5 2. Shalender Bhasin: Approach to the infertile man. J Clin Endo
& Metab 2007 June 92(6):1995-2004 3. Ferlin A, Arredi B, Speltra E, et al: Molecular and clinical
characterization of Y chromosome microdeletions in infertile men: A 10-year experience in Italy. J Clin
Endo & Metab. 2007
Yeast (Saccaromyces cerevisiae) IgG
Reference Values: