Sorted By Test Name - Mayo Medical Laboratories

F100B
57349
AASCA
83022
6 > or =100 Strongly positive Reference values
apply to all ages.
Clinical References: Homburger HA: Allergic diseases. In Clinical Diagnosis and Management by
Laboratory Methods. 21st edition. Edited by McPherson RA, Pincus MR. WB Saunders, Publ, New York,
2007 Chapter 53, Part VI, pp 961-971
S-100B Protein, Serum
Reference Values:
0 – 96 ng/L
This assay is performed using the CanAg S100 Enzyme Immunoassay. Results obtained with different
assay methods or kits cannot be used interchangeably.
Test Performed by: ARUP Laboratories
500 Chipeta Way
St. Lake City, UT 84108
Saccharomyces cerevisiae Antibody, IgA, Serum
Clinical Information: Inflammatory bowel disease (IBD) refers to 2 diseases, ulcerative colitis (UC)
and Crohn's disease (CD), that produce inflammation of the large or small intestines.(1) The diagnoses of
both diseases are based on clinical features, the results of barium X-rays, colonoscopy, mucosal biopsy
histology, and in some cases operative findings and resected bowel pathology and histology. Recently,
patients with IBD have been shown to have antibodies in serum that help distinguish between CD and
UC.(2) Patients with UC often have measurable neutrophil-specific antibodies, which react with as yet
uncharacterized target antigens in human neutrophils; whereas, patients with CD often have measurable
antibodies of the IgA and/or IgG isotypes, which react with cell wall mannan of Saccharomyces
cerevisiae strain Su 1.
Useful For: Helping clinicians distinguish between ulcerative colitis and Crohnâ€s disease in
patients suspected of having inflammatory bowel disease
Interpretation: In #81443 "Inflammatory Bowel Disease Serology Panel, Serum." ASCA and
neutrophil-specific antibodies (NSA) are measured. The finding of NSA with normal levels of IgA and
IgG ASCA is consistent with the diagnosis of ulcerative colitis (UC); the finding of negative NSA with
elevated IgA and IgG ASCA is consistent with Crohn's disease (CD). NSA are detectable in
approximately 50% of patients with UC. Elevated levels of either IgA or IgG ASCA occur in
approximately 55% of patients with CD. Approximately 40% of patients with CD have elevated levels of
both IgA and IgG ASCA. Employed together, the tests for NSA and ASCA have the following positive
predictive values (PPV) for UC and CD, respectively:(2) -NSA positive with normal levels of IgA and
IgG ASCA, PPV of 91% -NSA negative with elevated levels of IgA and IgG ASCA, PPV of 90%
Reference Values:
Negative: 0.0-20.0 U
Equivocal: 20.1-24.9 U
Weakly positive: 25.0-34.9 U
Positive: > or =35.0 U
Clinical References: 1. Rose, Noel, and Mackay Ian. The Autoimmune Diseases: Inflammatory
Bowel Diseases. New York, NY, Elsevier Academic Press, 2008 2. Sandborn WJ, Loftus EV Jr,
Homburger HA, et al: Evaluation of serological disease markers in a population-based cohort of patients
with ulcerative colitis and Crohn's disease. Inflamm Bowel Dis 2001 Aug;7(3):192-201
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