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80172
significance" (ASCUS) on Pap smear, HPV typing may be used to determine the need for
colposcopy.(5-7) Patients who are negative may be followed according to the usual clinical practice.
While certain HPV types are strongly associated with cervical cancer, there is clear evidence that
cofactors are involved. The nature and roles of these cofactors are under intense study; however, their
contributions to malignant progression are still poorly understood. Some of the cofactors thought to
interact with cancer-associated HPV types in the genesis of cervical malignancy are the herpes viruses,
tobacco products, oral contraceptives, and certain dietary factors.
Useful For: Detection of high-risk genotypes associated with the development of cervical cancer (3,4)
As an aid to triaging women with abnormal Pap smear results
Interpretation: A positive result indicates the presence of human papillomavirus (HPV) DNA due to 1
or more of the following genotypes of the virus: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68. A
negative result indicates the absence of HPV DNA of the target genotypes. For patients with ASCUS Pap
smear results and positive for high-risk HPV types, consider referral for colposcopy if clinically
indicated.(5-7)
Reference Values:
Negative for types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68
Clinical References: 1. Sanclemente G, Gill DK: Human papillomavirus molecular biology and
pathogenesis. J Eur Acad Dermatol Venereol 2001;16(3):231-240 2. Castle PE, Wacholder S, Lorincz
AT, et al: A prospective study of high-grade cervical neoplasia risk among human
papillomavirus-infected women. J Natl Cancer Inst 2002;94(18):1406-1414 3. Brentjens MH, Yeung-Yue
KA, Lee PC, Tyring SK: Human papillomavirus: a review. Dermatol Clin 2002;20(2):315-331 4.
Hagensee ME: Infection with human papillomavirus: update on epidemiology, diagnosis treatment. Curr
Infect Dis Rep 2000;2(1):18-24 5. Nguyen HN, Nordqvist SR: The bethesda system and evaluation of
abnormal pap smears. Semin Surg Oncol 1999;16(3):217-221 6. Wright TC Jr, Cox JT, Massad LS: 2001
consensus guidelines for the management of women with cervical cytological abnormalities. JAMA
2002;287(16):2120-2129 7. Crum CP, Berkowitz RS: Human papillomaviruses. Applications, caveats and
prevention. J Reprod Med 2002;47(7):519-528
Human Papillomavirus (HPV) Typing In Situ DNA Hybridization
Clinical Information: Many human papillomavirus (HPV)-induced lesions are benign presenting as
warts or condylomas. However, certain HPV types have been strongly associated with risk of
development of cervical, vaginal, and vulvar malignancy.
Useful For: The detection of specific human papillomavirus DNA types in paraffin-embedded human
tissue. These are type 6/11, and/or 16/18/31/33/35/39/45/51/52/56/58/66.
Interpretation: Human papillomavirus (HPV) types 6 and 11 are the predominant viruses associated
with condyloma acuminata (genital warts). The condition usually remains benign. HPV types
16/18/31/33/35/39/45/51/52/56/58/66 frequently are found in CIN III (severe dysplasias and carcinoma in
situ) and cervical cancer.
Reference Values:
Results are reported as positive or negative for types 6, 11, and/or types 16, 18, 31, 33, 35, 39, 45, 51, 52,
56, 58, and 66.
If additional interpretation/analysis is needed, please request 5439 Surgical Pathology Consultation
along with this test.
Clinical References: 1. Lorincz AT, Lancaster WD, Kurman RJ, et al: Characterization of human
papillomaviruses in cervical neoplasias and their detection in routine clinical screening. Banbury Rep
1986;21:225-237 2. Faulkner-Jones BE, Tabrizi SN, Borg AJ, et al: Detection of human papillomavirus
DNA and mRNA using synthetic, type-specific oligonucleotide probes. J Virol Methods 1993;41:277-296
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