Sorted By Test Name - Mayo Medical Laboratories

PTOX
81795
FFTXG
91211
FFTXM
INTERPRETIVE CRITERIA:
or = 1.10 Antibody detected
Diagnosis of central nervous system infections can be
accomplished by demonstrating the presence of
intrathecally-produced specific antibody. Interpreting
results may be complicated by low antibody levels found
in CSF, passive transfer of antibody from blood, and
contamination via bloody taps. The interpretation of CSF
results must consider CSF-serum antibody ratios to the
infectious agent.
Test Performed by
Focus Diagnostics, Inc.
5785 Corporate Avenue
Cypress, CA 90630-4750
Toxoplasma gondii, Molecular Detection, PCR
Clinical Information: Toxoplasma gondii is an intracellular protozoan parasite that chronically
infects about 10% of the adult population in the United States. Transmission may occur by ingestion of
undercooked meat containing cysts, by direct contact with the feces of an infected cat excreting infectious
oocysts, and vertically through the placenta. Accurate diagnosis is crucial because of the different
therapeutic options. Central nervous system (CNS) toxoplasmosis most often occurs as a complication of
HIV infection. Diagnosis of CNS toxoplasmosis is difficult by serologic methods, and direct detection of
the organism in cerebrospinal fluid (CSF) by stain and culture is not sensitive. PCR detection of
Toxoplasma gondii DNA in CSF is a rapid, sensitive, and specific method for the diagnosis of CNS
toxoplasmosis.
Useful For: Diagnosing central nervous system toxoplasmosis
Interpretation: A positive result indicates presence of DNA from Toxoplasma gondii. Negative results
indicate absence of detectable DNA but does not exclude the presence of organism or active or recent
disease.
Reference Values:
Negative for the presence of Toxoplasma gondii DNA
Clinical References: 1. Luft BJ, Remington JS: Toxoplasmic encephalitis in AIDS. Clin Infect Dis
1992 Aug;15(2):211-222 2. Sterkers Y, Varlet-Marie E, Marty P, et al: Diversity and evolution of
methods and practices for the molecular diagnosis of congenital toxoplasmosis in France: a four years
survey. Clin Microbiol Infect 2009 Nov 2 3. Villard O, Filisetti D, Roch-Deries F, et al: Comparison of
enzyme-linked immunosorbent assay, immunoblotting, and PCR for diagnosis of toxoplasmic
chorioretinitis. J Clin Microbiol 2003 Aug;41(8):3537-3541 4. Jones JL, Kruszon-Moran D,
Sanders-Lewis K, Wilson M: Toxoplasma gondii infection in the United States, 1999-2004, decline from
the prior decade. Am J Trop Med Hyg 2007 Sep;77(3):405-10
Toxoplasma IgG (Dye Test), Serum
Reference Values: