Sorted By Test Name - Mayo Medical Laboratories

FRTAL
88783
through 18 years of age: The Pediatric AIDS Clinical Trials Group P1009 study. J Allergy Clin Immunol
2003;112(5):973-980
Clinical References: 1. Carmichael KF, Abayomi A: Analysis of diurnal variation of lymphocyte
subsets in healthy subjects and its implication in HIV monitoring and treatment. 15th Intl Conference on
AIDS, Bangkok, Thailand, 2004, Abstract B11052 2. Dimitrov S, Benedict C, Heutling D, et al: Cortisol
and epinephrine control opposing circadian rhythms in T-cell subsets. Blood 2009;113(21):5134-5143 3.
Dimitrov S, Lange T, Nohroudi K, Born J: Number and function of circulating antigen presenting cells
regulated by sleep. Sleep 2007;30:401-411 4. Kronfol Z, Nair M, Zhang Q, et al: Circadian immune
measures in healthy volunteers: relationship to hypothalamic-pituitary-adrenal axis hormones and
sympathetic neurotransmitters. Psychosom Med 1997;59:42-50 5. Malone JL, Simms TE, Gray GC, et al:
Sources of variability in repeated T-helper lymphocyte counts from HIV 1-infected patients: total
lymphocyte count fluctuations and diurnal cycle are important. J AIDS 1990;3:144-151 6. Paglieroni TG,
Holland PV: Circannual variation in lymphocyte subsets, revisited. Transfusion 1994;34:512-516 7.
Mandy FF, Nicholson JK, McDougal JS: Guidelines for performing single-platform absolute CD4+T-cell
determinations with CD45 gating for persons infected with human immunodeficiency virus. Center for
Disease Control and Prevention. MMWR Morb Mortal Wkly Rep 2003;52:1-13 8. Centers for Disease
Control: 1997 Revised guidelines for performing CD4+ T-cell determinations in persons infected with
human immunodeficiency virus (HIV). MMWR Morb Mortal Wkly Rep 46 no. RR-2: 1997, pp 1-29 9.
U.S. Department of Health and Human Services: Recommendations for prophylaxis against Pneumocystis
carinii pneumonia for adults and adolescents infected with human immunodeficiency virus. MMWR
Morb Mortal Wkly Rep 43 no. RR-3: 1994, pp 1-21
T-Cell Acute Lymphoblastic Leukemia (T-ALL), FISH
Clinical Information: T-cell malignancies account for approximately 12% of all non-Hodgkin
lymphomas. There are several subtypes of T-cell neoplasms: T-cell acute lymphoblastic leukemia
(T-ALL), T-cell prolymphocytic leukemia (T-PLL), T-cell large granular lymphocytic leukemia (T-LGL),
anaplastic large cell lymphoma (ALCL), peripheral T-cell lymphoma, and various other cutaneous, nodal,
and extranodal lymphoma subtypes. The 2 most prevalent lymphoma subtypes are unspecified peripheral
T-cell lymphoma (3.7%) and ALCL (2.4%). T-ALL is a neoplastic disorder of lymphoblasts committed to
the T-cell lineage. These malignancies comprise 15% to 20% of acute leukemias. While half of T-ALL
patients have normal chromosome studies, molecular cytogenetic analysis can identify abnormalities
including: -Cryptic deletions of CDKN2A. -Rearrangements involving 1p32 (STIL/TAL1), 7q34 (TRB),
11q23 (MLL), and 14q11.2 (TRAD). -Chromosomal translocations including t(5;14)(q35;q32),
t(9;22)(q34;q11.2), t(10;11)(p13;q14), and various partner genes involved with the MLL and TRAD gene
loci. -Episomal amplification involving the ABL1/NUP214 fusion gene. These abnormalities may be seen
in tissues (ie, lymph nodes), as well as in blood and bone marrow. This assay detects the common
chromosome abnormalities observed in T-ALL. A few common chromosome abnormalities are associated
with specific T-cell lymphoma subtypes, including: -inv(14)(q11q32) and t(14;14)(q11;q32) involving the
T-cell leukemia/lymphoma 1 gene (TCL1A) at 14q32 -Translocations involving the ALK gene at 2p23 in
ALCL -Isochromosome 7q and trisomy 8 in hepatosplenic T-cell lymphoma For blood and bone marrow
specimens from patients with T-cell lymphomas, see FRTLP/89040 T-Cell Lymphoma, FISH, Blood or
Bone Marrow. These probes have diagnostic relevance and can also be used to track response to therapy.
Useful For: Detecting a neoplastic clone associated with the common chromosome abnormalities seen
in patients with T-cell acute lymphoblastic leukemia Tracking known chromosome abnormalities and
response to therapy in patients with T-cell acute lymphoblastic leukemia
Interpretation: A neoplastic clone is detected when the percent of cells with an abnormality exceeds
the normal reference range for any given probe. Detection of an abnormal clone is supportive of a
diagnosis of T-cell acute lymphoblastic leukemia (T-ALL). The specific anomaly detected may help
subtype the neoplasm. The absence of an abnormal clone does not rule out the presence of neoplastic
disorder.
Reference Values:
An interpretive report will be provided.
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