Sorted By Test Name - Mayo Medical Laboratories

GPI
9158
GLBF
8343
then rise again as stores are depleted, finally normalizing towards adult levels as regular feeding patterns
are established.
Clinical References: 1. Sherwood NM, Krueckl SL, McRory JE: The origin and function of the
pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily. Endocrin Rev 2000
Dec;21(6):619-670 2. Tomassetti P, Migliori M, Lalli S, et al: Epidemiology, clinical features and
diagnosis of gastroenteropancreatic endocrine tumours. Ann Oncol 2001;12 Suppl 2:S95-99 3. Cryer PE:
Hypoglycemia risk reduction in type 1 diabetes. Exp Clin Endocrinol Diabetes 2001;109 Suppl
2:S412-423 4. Jhiang G, Zhang BB: Glucagon and regulation of glucose metabolism. Am J Physiol Metab
2003;284:E671-E678 5. vanBeek AP, de Haas ER, van Vloten WA, et al: The glucagonoma syndrome
and necrolytic migratory erythema: a clinical review. Eu J Endocrinol 2004;151:531-537
Glucose Phosphate Isomerase, Erythrocytes
Clinical Information: Erythrocyte glucose phosphate isomerase (GPI) deficiency has been reported
as a cause of chronic hemolysis in numerous cases. Inheritance is autosomal recessive. Hemolytic disease
of the newborn is a common presenting manifestation of GPI deficiency.
Useful For: A second-order test in the evaluation of individuals with chronic hemolysis
Interpretation: 39.3 U/g hemoglobin to 57.7 U/g hemoglobin. Glucose phosphate isomerase (GPI)
deficiency causes a moderately severe anemia. GPI values can be 25% of normal. Increased GPI activity
may be seen when young RBCs are being produced in response to the anemia (reticulocytosis) or in the
case of the patient being a newborn.
Reference Values:
39.3-57.7 U/g hemoglobin
Clinical References: Fairbanks VF, Klee GG: Biochemical aspects of hematology. In Tietz
Textbook of Clinical Chemistry. 3rd Edition. Edited by CA Burtis, ER Ashwood, Philadelphia, WB
Saunders Company, 1999, pp 1642-1646
Glucose, Body Fluid
Clinical Information: Not available
Useful For: Not established
Interpretation: None available
Reference Values:
Not applicable
Clinical References: Tietz Textbook of Clinical Chemistry. Edited by Burtis and Ashwood. WB
Philadelphia, WB Saunders Company, 1994
800042 Glucose, Fasting, Plasma
Clinical Information: The most common disease related to carbohydrate metabolism is diabetes
mellitus. Insufficient blood levels of active insulin characterize diabetes mellitus. Symptoms include
polyuria, abnormally elevated blood and urine glucose values, excessive thirst, constant hunger, sudden
weight loss and possibly elevated blood and urine ketones. Complications from diabetes are the third
leading cause of death in the US. There are approximately 16 million diabetics in the US and that number
is growing. It is estimated that at least 5 million of these people have not been diagnosed. The prevalence
in the population age 65 and older is 18.4%, representing 6.3 million cases. The cost of diabetes to the US
economy exceeds $92 billion annually. Over production or excess administration of insulin causes a
decrease in blood glucose to levels below normal. In severe cases the resulting extreme hypoglycemia is
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