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HEPS<br />

200830<br />

Reference Values:<br />

HEPATITIS B SURFACE ANTIGEN<br />

Negative<br />

HEPATITIS B CORE TOTAL ANTIBODY<br />

Negative<br />

HEPATITIS A ANTIBODY, IgG & IgM<br />

Negative<br />

HEPATITIS B SURFACE ANTIBODY<br />

Unvaccinated: negative<br />

Vaccinated: positive<br />

HEPATITIS B SURFACE ANTIBODY, QUANTITATIVE<br />

Unvaccinated: or =12.0<br />

See Viral Hepatitis Serologic Profiles in Special Instructions.<br />

Clinical References: 1. Sherlock S: Hepatitis B: the disease. Vaccine 1990;8 Suppl:S6-S9 2. Lemon<br />

SM: Type A viral hepatitis: epidemiology, diagnosis, and prevention. Clin Chem 1997 August;43(8 pt<br />

2):1494-1499 3. Ciocca M: Clinical course and consequences of hepatitis A infection. Vaccine 2000;18<br />

Suppl 1: S71-74<br />

Hepatitis Screening Panel, Serum<br />

Clinical Information: Hepatitis A Hepatitis A virus (HAV) is endemic throughout the world,<br />

occurring most commonly, however, in areas of poor hygiene and low socioeconomic conditions. The<br />

virus, which is transmitted primarily by the fecal-oral route, is spread by close person-to-person contact<br />

and by food- and water-borne epidemics. Outbreaks frequently occur in overcrowded situations and in<br />

high-density institutions and centers, such as prisons and health-care or day-care centers. Viral spread by<br />

parenteral contact (with blood or oropharyngeal secretions) is possible but rare, because infected<br />

individuals are viremic for a short period of time (usually 50%) to chronic<br />

disease. In the United States, HCV infection is quite common, with an estimated 3.5 to 4 million chronic<br />

HCV carriers. Cirrhosis and hepatocellular carcinoma are sequelae of chronic HCV.<br />

Useful For: Screening to determine a patient's previous exposure to hepatitis Determining immunity to<br />

hepatitis A and B Determining if a patient has been infected following exposure to an unknown type of<br />

hepatitis<br />

Interpretation: Hepatitis A virus (HAV) infection Anti-HAV is usually detectable by the onset of<br />

symptoms (15-45 days after exposure). Serological diagnosis of acute HAV infection depends on the<br />

detection of IgM antibody and its presence indicates recent exposure and potential infectivity. Hepatitis B<br />

virus (HBV) infection Hepatitis B surface antigen (HBsAg) is the first serological marker present<br />

following HBV infection. A positive result is diagnostic of acute or chronic HBV infection and is<br />

Current as of January 4, 2013 7:15 pm CST 800-533-1710 or 507-266-5700 or <strong>Mayo</strong><strong>Medical</strong><strong>Laboratories</strong>.com Page 908

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