Sorted By Test Name - Mayo Medical Laboratories

TLB
8149
TLRU
60324
TLCRU
60325
1972;26:456-464 2. Pelclova D, Urban P, Ridson P, et al: Two-year follow-up of two patients after severe
thallium intoxication. Hum Exp Toxicol. 2009 May;28(5):263-272 3. Zhao G, Ding M, Zhang B, et al:
Clinical manifestations and management of acute thallium poisoning. Eur Neurol 2008;60(6):292-297
Thallium, Blood
Clinical Information: Thallium is a by-product of lead smelting. The clinical interest in thallium
derives primarily from its use as a rodenticide since this is the most frequent route of human exposure.
Thallium is rapidly absorbed via ingestion, inhalation, skin contact, and through the mucous membranes
of the mouth, gastrointestinal tract, and lungs. It is considered to be as toxic as lead and mercury, with
similar sites of action. The mechanism of action of thallium is: -Competition with potassium at cell
receptors to affect ion pumps -Inhibition of DNA synthesis -Binds to sulfhydryl groups on proteins in
neural axons -Concentrates in renal tubular cells and reacts with protein to cause necrosis Patients
exposed to high doses of thallium (>1 g) present with alopecia (hair loss), peripheral neuropathy and
seizures, and renal failure.
Useful For: Detecting toxic thallium exposure
Interpretation: Normal blood concentrations are 10 ng/mL, and blood concentrations as high as 50 ng/mL. The long-term sequelae
from such an exposure is poor.
Reference Values:
0-1 ng/mL
Reference values apply to all ages.
Clinical References: 1. Pelcloval D, Urbanl, P, Ridsonl P, et. al. Two-year follow-up of two patients
after severe thallium intoxication. Human & Experimental Toxicology 2009;28:263–272 2. Zhao G,
Ding M, Zhang B, et. Al. Clinical Manifestations and Management of Acute Thallium Poisoning. Eur
Neurol 2008;60:292–297
Thallium, Random, Urine
Clinical Information: Thallium is found in some depilatories and rodenticides. Accidental ingestion
may lead to vomiting, diarrhea, and leg pains followed by a severe and sometimes fatal sensorimotor
polyneuropathy and renal failure. Alopecia (hair loss) may occur 3 weeks after poisoning. The fatal dose
is approximately 1 g.
Useful For: Detecting toxic thallium exposure
Interpretation: Normal daily output is 10
mcg/day. The long-term consequences of such an exposure are poor.
Reference Values:
0-1 mcg/L
Reference values apply to all ages.
Clinical References: 1. Bank WJ, Pleasure DE, Suzuki K, et al: Thallium poisoning. Arch Neurol
1972;26:456-464 2. Pelclova D, Urban P, Ridson P, et al: Two-year follow-up of two patients after severe
thallium intoxication. Hum Exp Toxicol. 2009 May;28(5):263-272 3. Zhao G, Ding M, Zhang B, et al:
Clinical manifestations and management of acute thallium poisoning. Eur Neurol 2008;60(6):292-297
Thallium/Creatinine Ratio, Random, Urine
Clinical Information: Thallium is found in some depilatories and rodenticides. Accidental ingestion
may lead to vomiting, diarrhea, and leg pains followed by a severe and sometimes fatal sensorimotor
polyneuropathy. Alopecia (hair loss) may occur 3 weeks after poisoning. The fatal dose is approximately
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