Sorted By Test Name - Mayo Medical Laboratories

FKAL
88540
FKAN
90069
Results are expressed in mcg/mL
Kaletra levels peak approximately 4 hours after administration of
400 mg lopinavir/100 mg ritonavir. The mean peak concentration
is approximately 22% lower for the oral solution than the capsule
formulation under fasting conditions. To enhance bioavailability,
Kaletra oral suspension should be taken with food.
HIV-1 infected adults, 400/100 mg twice daily x 3 weeks.
Lopinavir mean steady state trough level:
7.1 + or - 2.9 mcg/mL
Lopinavir mean peak level:
9.8 + or - 3.7 mcg/mL
Pediatric lopinavir levels are similar to those obtained in adult patients.
Test Performed by: Focus Diagnostics, Inc.
5785 Corporate Ave.
Cypress, CA 90630-4750
Kallmann Syndrome, Xp22.3 Deletion, FISH
Clinical Information: Kallmann syndrome is associated with a deletion on the short arm of the X
chromosome. The syndrome is an X-linked disease and can be suspected in patients with complete
absence of smell (anosmia), hypogonadism, and delayed sexual development. The phenotype may include
gynecomastia, bimanual synkinesis (1 hand copying the movements of the other hand), shortened fourth
metacarpal bone, and absence of a kidney. Kallmann syndrome affects mainly males, but rare cases of
affected females have been reported. FISH studies are highly specific and do not exclude other
chromosome abnormalities. For this reason, we recommend that patients suspected of having Kallmann
syndrome also have conventional chromosome studies (CMS/8696 Chromosome Analysis, for Congenital
Disorders, Blood) performed to rule out other chromosome abnormalities or translocations.
Useful For: Aids in the diagnosis of Kallmann syndrome, in conjunction with conventional
chromosome studies (CMS/8696 Chromosome Analysis, for Congenital Disorders, Blood) Detecting
cryptic translocations involving Xp22.3 that are not demonstrated by conventional chromosome studies
Interpretation: Any individual with a normal signal pattern (2 signals in females and 1 signal in
males) in each metaphase is considered negative for a deletion in the region tested by this probe. Any
patient with a FISH signal pattern indicating loss of the critical region on an X chromosome will be
reported as having a deletion of the regions tested by this probe. This is consistent with a diagnosis of
Kallmann syndrome (Xp22.3 deletion).
Reference Values:
An interpretive report will be provided.
Clinical References: 1. Meitinger T, Heye B, Petit C, et al: Definitive localization of X-linked
Kallmann syndrome (hypogonadotropic hypogonadism and anosmia) to Xp22.3: close linkage to the
hypervariable repeat sequence CRI-S232. Am J Hum Genet 1990 Oct;47(4):664-669 2. Weissortel R,
Strom TM, Dorr HG, et al: Analysis of an interstitial deletion in a patient with Kallmann syndrome,
X-linked ichthyosis and mental retardation. Clin Genet 1998 Jul;54(1):45-51
Kanamycin Level, BA
Reference Values:
Peak levels, IM or IV, 1 hr: 22 mcg/mL
Trough levels, IM or IV, 8 hrs: 3.2 mcg/mL
Any undisclosed antimicrobials might affect the results.
Current as of January 4, 2013 7:15 pm CST 800-533-1710 or 507-266-5700 or MayoMedicalLaboratories.com Page 1068