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89045
proteins) followed by respiratory disease (rhinitis and asthma) in older children and adults due to
sensitivity to inhalant allergens (dust mite, mold, and pollen inhalants).
Useful For: Testing for IgE antibodies may be useful to establish the diagnosis of an allergic disease
and to define the allergens responsible for eliciting signs and symptoms. Testing also may be useful to
identify allergens which may be responsible for allergic disease and/or anaphylactic episode, to confirm
sensitization to particular allergens prior to beginning immunotherapy, and to investigate the specificity of
allergic reactions to insect venom allergens, drugs, or chemical allergens.
Interpretation: Detection of IgE antibodies in serum (Class 1 or greater) indicates an increased
likelihood of allergic disease as opposed to other etiologies and defines the allergens that may be
responsible for eliciting signs and symptoms. The level of IgE antibodies in serum varies directly with the
concentration of IgE antibodies expressed as a class score or kU/L.
Reference Values:
Class IgE kU/L Interpretation
0 Negative
1 0.35-0.69 Equivocal
2 0.70-3.49 Positive
3 3.50-17.4 Positive
4 17.5-49.9 Strongly positive
5 50.0-99.9 Strongly positive
6 > or =100 Strongly positive Reference values
apply to all ages.
Clinical References: Homburger HA: Allergic diseases. In Clinical Diagnosis and Management by
Laboratory Methods. 21st edition. Edited by McPherson RA, Pincus MR. WB Saunders, Publ, New York,
Chapter 53, Part VI, pp. 961-971, 2007
BRAF Mutation (T1799A) Analysis by PCR and Sequencing,
Thyroid
Clinical Information: Papillary thyroid carcinoma (PTC) accounts for approximately 80% of all
thyroid cancers. The BRAF gene mutation (T1799A) in exon 15 is the most common genetic alteration in
thyroid cancer, occurring in 30% to 70% of sporadic PTC and 10% to 30% of anaplastic thyroid
carcinoma, but not in other types of thyroid tumors.(1-3) Fine-needle aspiration (FNA) biopsy with
cytological analysis is the best preoperative diagnostic method for thyroid tumors, but 15% to 20% of
FNA biopsies yield indeterminate results. Detection of the BRAF mutation (T1799A) can help in the
diagnosis of thyroid tumors, especially for indeterminate cases.
Useful For: Aiding in the diagnosis of papillary thyroid carcinoma or anaplastic thyroid carcinoma in
fine-needle aspirate specimens and formalin-fixed, paraffin-embedded tissue
Interpretation: A negative result does not rule-out the presence of a mutation. A positive result
supports a diagnosis of papillary thyroid carcinoma (PTC) or anaplastic thyroid carcinoma (ATC), but a
negative result does not necessarily rule-out a diagnosis of PTC or ATC.
Reference Values:
Negative
Clinical References: 1. Jin L, Sebo TJ, Nakamura N, et al: BRAF mutation analysis in fine needle
aspiration (FNA) cytology of the thyroid. Diagn Mol Pathol 2006;15:136-143 2. Nakamura N, Carney JA,
Jin L, et al: RASSF1A and NORE1A methylation and BRAFV600E mutations in thyroid tumors. Lab
Invest 2005;85:1065-1075 3. Nikiforova MN, Kimura ET, Gandhi M, et al: BRAF mutations in thyroid
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