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Clinical References: Tisher CC: Clinical indication for kidney biopsy. In Renal Pathology: with
Clinical and Functional Correlations. Vol. II. 2nd edition. Edited by CC Tisher, BM Brenner.
Philadelphia, JB Lippincott Book Company, 1989, pp 2-10
Renal Biopsy, Immunohistology
Clinical Information: Kidney biopsy has proven to be of value in the clinical evaluation and
management of patients with undiagnosed kidney disease. The clinical setting may include acute renal
failure, nephrotic syndrome, asymptomatic proteinuria and hematuria. Kidney diseases in the setting of a
systemic disease are often diagnosed on kidney biopsy. Biopsy of the transplanted kidney is important in
the determination of the presence of acute rejection, infection, or recurrent disease. Optimal interpretation
of a kidney biopsy requires integration of clinical and laboratory results with light microscopic,
immunofluorescent histology, and electron microscopy findings. Immunofluorescent histology is
necessary in the diagnosis of immune complex mediated disease such and IgA nephropathy, membranous
nephropathy, and post-infectious glomerulonephritis; for evaluation of light-chain related disease such as
amyloidosis, light-chain deposition disease, and light-chain cast nephropathy, and other immune-mediated
diseases such as Goodpasture's disease and lupus nephritis.
Useful For: The evaluation of patients with undiagnosed kidney disease Following the course of
therapy or progression of disease Diagnosing disease cause by immune mechanisms The evaluation of
kidney and/or lung specimens for Goodpastureâ€s disease
Interpretation: A written report is issued upon completion of immunohistologic examination. If
material is also submitted for light microscopy, the immunohistologic report will be incorporated with the
light microscopic findings and a written report will be issued.
Reference Values:
An interpretive report will be provided.
Clinical References: Velosa JA, Holley KE: Pathology and immunopathology of renal diseases. In
Renal Function Tests: Clinical Laboratory Procedures and Disorders. Edited by CG Duarte. Boston, MA,
Little, Brown, and Company, 1980, pp 347-385
Renal Biopsy, Light Microscopy
Clinical Information: Kidney biopsy has proven to be of value in the clinical evaluation and
management of patients with undiagnosed kidney disease. The clinical setting may include acute renal
failure, nephrotic syndrome, asymptomatic proteinuria and hematuria. Kidney diseases in the setting of a
systemic disease are often diagnosed on kidney biopsy. Biopsy of the transplanted kidney is important in
the determination of the presence of acute rejection, infection, or recurrent disease. Optimal interpretation
of a kidney biopsy requires integration of clinical and laboratory results with light microscopic,
immunofluorescent histology, and electron microscopy findings. Tissue should always be submitted for
evaluation by light microscopy. In some instances, electron microscopy is required (eg, Alport's
syndrome, dense deposit disease, minimal change nephropathy, thin basement membrane disease, etc.) to
make an accurate diagnosis and submission of tissue for immunofluorescent histology is required to
evaluate for immune complex mediated disease. We recommend that additional material be submitted for
evaluation by immunohistologic method.
Useful For: The evaluation of patients with undiagnosed kidney disease Following the progression of
disease or response to therapy Determining the cause of dysfunction in the transplanted kidney (allograft)
Interpretation: A verbal report is given by phone upon completion of the light microscopic
examination. A written report is subsequently issued along with histologic slides, and will incorporate
results of immunfluorescent histology and/or electron microscopy if performed.
Reference Values:
An interpretive report will be provided.
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