Sorted By Test Name - Mayo Medical Laboratories

CROMU
89547
CRU
8593
95% specific for SLE; in addition, chromatin antibodies are also more sensitive and specific than histone
antibodies for identifying patients with drug-induced lupus. Recent studies further demonstrate that
chromatin antibodies are present in about 40% of patients with autoimmune hepatitis, and identify
patients with active disease who commonly relapse after drug withdrawal. Other names used for
chromatin antibodies include LE-cell factor, DNP antibodies, and (H2A-H2B)-DNA antibodies.
Test Performed by: Focus Diagnostics, Inc.
5785 Corporate Ave
Cypress, CA 90630-4750
Chromium for Occupational Monitoring, Urine
Clinical Information: Chromium (Cr) has an atomic mass of 51.996, atomic number 24, and
valences ranging from 2(-) to 6(+). Hexavalent chromium, Cr(+6), and trivalent chromium, Cr(+3), are
the 2 most prevalent forms. Cr(+3) is the only oxidation state present under normal physiologic
conditions. Cr(+6) is widely used in industry to make chromium alloys including stainless steel pigments
and electroplated coatings. Cr(+6), a known carcinogen, is rapidly metabolized to Cr(+3). Cr(+3) is the
only form present in human urine.
Useful For: Screening for occupational exposure
Interpretation: The National Institute for Occupational Safety and Health (NIOSH) draft document on
occupational exposure reviews the data supporting use of urine to assess chromium exposure.(1) They
recommend a Biological Exposure Index of 10 mcg/g creatinine and 30 mcg/g creatinine for the increase
in urinary chromium concentrations during a work shift and at the end of shift at the end of the workweek,
respectively (Section 3.3.1).
Reference Values:
Chromium/creatinine ratio: 20 mcg/24 hour in a patient
with chromium-based implant suggest significant prosthesis wear. Increased urine trace element
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