Sorted By Test Name - Mayo Medical Laboratories

BNP
83873
CD19+ CD20+ 3.2-16.8 95.0-580.8
Results Expressed as a Percentage of CD19+ B Cells Percentage Absolute Count (Cells/mcL)
CD19+ CD27+ 6.3-52.8 18.0-145.0
CD19+ CD27+ IgM+ IgD+ 1.7-29.3 4.0-85.0
CD19+ CD27+ IgM- IgD- 2.3-26.5 7.0-61.0
CD19+ CD27+ IgM+ IgD- 0-5.3 0-12.0
CD19+ IgM+ 26.0-78.0 37.0-327.0
CD19+ CD38+ IgM- 4.1-42.2 7.0-153.0
CD19+ CD38+ IgM+ 1.2-50.7 2.0-139.4
CD19+ CD21+ 92.1-99.6 85.0-533.0
CD19+ CD21- 0.2-8.6 0.3-22.0
Clinical References: T- and B-Cell Quantitation by Flow Cytometry: 1. Carmichael KF, Abayomi
A: Analysis of diurnal variation of lymphocyte subsets in healthy subjects and its implication in HIV
monitoring and treatment. 15th Intl Conference on AIDS, Bangkok, Thailand, 2004, Abstract B11052 2.
Dimitrov S, Benedict C, Heutling D, et al: Cortisol and epinephrine control opposing circadian rhythms in
T-cell subsets. Blood 2009;113(21):5134-5143 3. Dimitrov S, Lange T, Nohroudi K, Born J: Number and
function of circulating antigen presenting cells regulated by sleep. Sleep 2007;30:401-411 4. Kronfol Z,
Nair M, Zhang Q, et al: Circadian immune measures in healthy volunteers: relationship to
hypothalamic-pituitary-adrenal axis hormones and sympathetic neurotransmitters. Psychosom Med
1997;59:42-50 5. Malone JL, Simms TE, Gray GC, et al: Sources of variability in repeated T-helper
lymphocyte counts from HIV 1-infected patients: total lymphocyte count fluctuations and diurnal cycle
are important. J AIDS 1990;3:144-151 6. Paglieroni TG, Holland PV: Circannual variation in lymphocyte
subsets, revisited. Transfusion 1994;34:512-516 Immune Assessment B Cell Subsets, Blood: 1. Warnatz
K, Denz A, Drager R, et al: Severe deficiency of switched memory B cells (CD27+ IgM- IgD-) in
subgroups of patients with common variable immunodeficiency: a new approach to classify a
heterogeneous disease. Blood 2002;99:1544-1551 2. Brouet JC, Chedeville A, Fermand JP, Royer B:
Study of the B cell memory compartment in common variable immunodeficiency. Eur J Immunol
2000;30:2516-2520 3. Wehr C, Kivioja T, Schmitt C, et al: The EUROclass trial: defining subgroups in
common variable immunodeficiency. Blood 2008;111:77-85 4. Alachkar H, Taubenheim N, Haeney MR,
et al: Memory switched B-cell percentage and not serum immunoglobulin concentration is associated with
clinical complications in children and adults with specific antibody deficiency and common variable
immunodeficiency. Clin Immunol 2006;120:310-318 5. Lee WI, Torgerson TR, Schumacher MJ, et al:
Molecular analysis of a large cohort of patients with hyper immunoglobulin M (hyper IgM) syndrome.
Blood 2005;105:1881-1890
B-Type Natriuretic Peptide (BNP), Plasma
Clinical Information: B-type natriuretic peptide (brain natriuretic peptide; BNP) is a 32-amino
acid-ringed peptide secreted by the heart to regulate blood pressure and fluid balance.(1) BNP is stored in
and secreted predominantly from membrane granules in the heart ventricles, and is continuously released
from the heart in response to both ventricle volume expansion and pressure overload.(2) The natriuretic
peptide system and the renin-angiotensin system counteract each other in arterial pressure regulation.
When arterial pressure decreases, the kidneys release renin, which activates angiotensinogen resulting in
increased peripheral resistance of the arterioles, thus increasing arterial pressure. The natriuretic peptides
counteract the effects of rennin secretion, causing a reduction of blood pressure and in extracellular fluid
volume.(3) Both BNP and atrial natriuretic peptide (ANP) are activated by atrial and ventricular
distension due to increased intracardiac pressure. These peptides have both natriuretic and diuretic
properties: they raise sodium and water excretion by increasing the glomerular filtration rate and
inhibiting sodium reabsorption by the kidney. The New York Heart Association (NYHA) developed a
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