Sorted By Test Name - Mayo Medical Laboratories

FMMS
91939
ME2MS
89284
Interpretation: Detection of IgE antibodies in serum (Class 1 or greater) indicates an increased
likelihood of allergic disease as opposed to other etiologies and defines the allergens that may be
responsible for eliciting signs and symptoms. The level of IgE antibodies in serum varies directly with the
concentration of IgE antibodies expressed as a class score or kU/L.
Reference Values:
Class IgE kU/L Interpretation
0 Negative
1 0.35-0.69 Equivocal
2 0.70-3.49 Positive
3 3.50-17.4 Positive
4 17.5-49.9 Strongly positive
5 50.0-99.9 Strongly positive
6 > or =100 Strongly positive Reference values
apply to all ages.
Clinical References: Homburger HA: Allergic diseases. In Clinical Diagnosis and Management by
Laboratory Methods. 21st edition. Edited by McPherson RA, Pincus MR. WB Saunders, Publ, New York,
Chapter 53, Part VI, pp. 961-971, 2007
Meconium Methadone Screen
Reference Values:
The specimen was screened by Immunoassay at the following
threshold concentrations.
Methadone: 300 ng/gm
Positive results are confirmed by Gas Chromatography with
Mass Spectrometry (GC/MS) to limit of detection.
Test Performed by: Medtox Laboratories, Inc.
402 W County Road D
St. Paul, MN 55112
MECP2 Gene, Full Gene Analysis
Clinical Information: Methyl-CpG-binding protein 2 (MeCP2) is a transcriptional repressor protein
encoded by the MECP2 gene located on the X chromosome. Genetic mutations in MECP2 alter the
expression of targeted genes and can be associated with variable phenotypes in females including classic
Rett syndrome, variant or atypical Rett syndrome, mild mental retardation, and asymptomatic carriers.
Males with MECP2 mutations can present with variable phenotypes as well. The variability in males can,
in part, be attributed to the type of MECP2 mutation present; point mutations are typically associated with
severe neonatal encephalopathy and gene duplications are associated with MECP2 duplication syndrome.
Full MECP2 gene analysis via sequencing and large duplication/deletion studies has been useful in
identifying germline mutations in individuals with these clinical presentations. Rett Syndrome Rett
syndrome is an X-linked, panethnic condition with an incidence of approximately 1/8,500 to 1/15,000
females. Disease course typically begins after 6 to 18 months of apparently normal development with
rapid regression in language and motor skills. A hallmark feature of this condition is repetitive,
stereotyped hand movements, sometimes described as hand-wringing. Clinical criteria have been
established for diagnosis of classic and atypical or variant Rett syndrome. Greater than 88% of females
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