Sorted By Test Name - Mayo Medical Laboratories

SCL70
80178
OXK
8148
SEAFP
31770
Scl 70 Antibodies, IgG, Serum
Clinical Information: Scl 70 (topoisomerase 1) is a 100-kD nuclear and nucleolar enzyme. Scl 70
antibodies are considered to be specific for scleroderma (systemic sclerosis) and are found in up to 60% of
patients with this connective tissue disease. Scl 70 antibodies are more common in patients with extensive
cutaneous involvement and interstitial pulmonary fibrosis, and are considered a poor prognostic sign.(1,2)
See Connective Tissue Disease Cascade (CTDC) in Special Instructions and Optimized Laboratory
Testing for Connective Tissue Diseases in Primary Care: The Mayo Connective Tissue Diseases Cascade
in Publications.
Useful For: Evaluating patients with signs and symptoms of scleroderma and other connective tissue
diseases in whom the test for antinuclear antibodies is positive
Interpretation: A positive test result for Scl 70 antibodies is consistent with a diagnosis of
scleroderma.
Reference Values:
or =1.0 U (positive)
Reference values apply to all ages.
Clinical References: 1. Homburger H, Larsen S: Detection of specific antibodies. In Clinical
Immunology: Principles and Practice. 1st edition. Edited by R Rich, T Fleisher, B Schwartz, et al. St.
Louis, Mosby-Year Book, Inc, 1996, pp 2096-2109 2. White B: Systemic sclerosis. In Clinical
Immunology Principles and Practice. 2nd edition. Edited by R Rich, T Fleisher, W Shearer, et al. St.
Louis, Mosby-Year Book, 2001, pp 64.1-64.10
Scrub Typhus Antibodies, Serum
Clinical Information: Scrub typhus is an acute infectious disease transmitted to man by the bites of
mites. Orienta tsutsugamushi, the etiologic agent, is transmitted into the skin by the bite of the larval mite.
The spectrum of clinical severity ranges from inapparent and mild to severe or fatal. An initial lesion
usually develops at the site of a chigger bite. It later becomes papulovesicular and forms a black scab
which becomes the eschar. Regional lymphadenopathy is common followed by a macular rash which
occurs between the 5th and 8th days of illness. Fever is common and may rise to 40 degrees C to 45
degrees C. Conjunctivitis and hepatosplenomegaly are also common manifestations. Multi-organ
vasculitis of the small blood vessels occurs. Acute hepatitis or granulomatous hepatitis can be a
complication of scrub typhus. Treatment is with chloramphenicol or tetracyclines.
Useful For: As an aid to the diagnosis of scrub typhus infections
Interpretation: An agglutinin titer of > or =1:160 is suggestive of active infection. Agglutinins appear
7 to 15 days after the onset of disease. Titers peak during the third week and decline rapidly over the next
few months. Antibodies are found in only approximately 50% of cases within the second week of illness.
A 4-fold or greater rise in paired sera titer is suggestive of recent infection. However, only 50% to 70% of
patients with scrub typhus exhibit a 4-fold rise in titer.
Reference Values:
Negative
Clinical References: 1. Chi WC, Huang JJ, Sung JM, et al: Scrub typhus associated with multiorgan
failure: a case report. Scand J Infect Dis 1997;29:634-635 2. Chien RN, Liu NJ, Lin PY, Liaw YF:
Granulomatous hepatitis associated with scrub typhus. J Gastroenterol Hepatol 1995;10:484-487
Seafood Allergen Profile
Clinical Information: Clinical manifestations of immediate hypersensitivity (allergic) diseases are
caused by the release of proinflammatory mediators (histamine, leukotrienes, and prostaglandins) from
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