Sorted By Test Name - Mayo Medical Laboratories

FCAH
91165
immaturity of the neonatal liver. This requires that small doses be administered at much longer intervals
than would be predicted based on adult pharmacokinetics. The volume of distribution of caffeine is 0.6
L/kg and the drug is approximately 35% protein bound. Toxicity observed in neonates is characterized by
central nervous system and skeletal muscle stimulation and bradycardia. These symptoms are seen in
adults at lower levels than in neonates, suggesting that neonates have much greater tolerance to the drug.
Useful For: Monitoring therapy in neonates Assessing toxicity in neonates
Interpretation: Optimal pharmacologic response occurs when the serum level is in the range of 5
mcg/mL to 15 mcg/mL. Toxicity in neonates and adults may be seen when the serum level is > or =20
mcg/mL.
Reference Values:
Therapeutic concentration: 5-15 mcg/mL
Toxic concentration: > or =30 mcg/mL
Clinical References: Ou CN, Frawley VL: Concurrent measurement of theophylline and caffeine in
neonates by an interference-free liquid-chromatographic method. Clin Chem 1983;29:1934-1936
CAH Pediatric Profile 5: 17,20 Desmolase Deficiency
(Androstenedione,
Cortisol, DHEA, 17-OH-Prenenolone, Progesterone,
17-Alpha-
Hydroxyprogesterone, Testosterone)
Reference Values:
Androstenedione, Mass Spec
Units: ng/dL
Age Range
Premature (26-28w) Day 4 63 - 935
Premature (31-35w) Day 4 50 - 449
Full Term (1 week)