Sorted By Test Name - Mayo Medical Laboratories

RIB
87837
RICE
82709
human body. Oxford, Blackwell Publishing, 2004, pp 289-299 3. McCormick DB: Riboflavin. In Modern
Nutrition in Health and Disease. 10th edition. Edited by ME Shils, M Shike, AC Ross, et al. Philadelphia,
Lippincott Williams and Wilkins, 2006, pp 434-441 4. Hustad S, McKinley MC, McNulty H, et al.
Riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in human plasma and erythrocytes at
baseline and after low-dose riboflavin supplementation. Clin Chem 2002;48:1571 5. Midttun O, Hustad S,
Solheim E, et al. Multianalyte quantification of vitamin B6 and B2 species in the nanomolar range in
human plasma by liquid chromatography-tandem mass spectrometry. Clin Chem 2005;51:1206 6.
Capo-chichi CD, Gueant J-L, Lefebvre E, et al. Riboflavin and riboflavin-derived cofactors in adolescent
girls with anorexia nervosa. Am J Clin Nutr 1999;69:672
Ribosome P Antibodies, IgG, Serum
Clinical Information: The 80S mammalian ribosome is composed of approximately equal amounts
of protein and RNA. The larger 60S subunit contains 3 acidic phosphoproteins, PO, P1, and P2 with
molecular masses of 38 kDa, 19 kDa, and 17 kDa, respectively. The major immunoreactive epitope of
these 3 autoantigens is found within 22 consecutive amino acids of the carboxy terminus of these 3 highly
conserved proteins. It has been known for some time that sera from some patients with lupus
erythematosus (LE) react with ribosomal protein antigens. Studies performed with synthetic peptide
antigens revealed that reactivity detected by immunoprecipitation and by immunofluorescence methods in
sera from LE patients was directed at the above mentioned epitope. Antibodies to ribosome P proteins are
considered highly specific for LE, and have been reported in patients with central nervous system (CNS)
involvement and so called "lupus psychosis." The reported frequency of antibodies to ribosome P protein
autoantigens in patients with LE is approximately 12%. Since patients with LE may manifest signs and
symptoms of CNS diseases including neuropsychiatric symptoms, the presence of antibodies to ribosome
P protein may be useful in the differential diagnosis of such patients. Other causes of CNS symptoms in
patients with LE include thrombosis with or without antibodies to phospholipid antigens and iatrogenic
effects from treatment with corticosteroid drugs.
Useful For: As an adjunct in the evaluation of patients with lupus erythematosus (LE) As an aid in the
differential diagnosis of neuropsychiatric symptoms in patients with LE
Interpretation: A positive result is consistent with the diagnosis of lupus erythematosus, and may
indicate the presence of central nervous system involvement.
Reference Values:
or =1.0 U (positive)
Reference values apply to all ages.
Clinical References: 1. Bonfa E, Golombek SJ, Kaufman LD, et al: Association between lupus
psychosis and anti-ribosomal P protein antibodies. N Engl J Med 1987;317:265-271 2. Bonfa E, Elkon
KB: Clinical and serologic associations of the anti-ribosomal P protein antibody. Arthritis Rheum
1986;29:981-985
Rice, IgE
Clinical Information: Clinical manifestations of immediate hypersensitivity (allergic) diseases are
caused by the release of proinflammatory mediators (histamine, leukotrienes, and prostaglandins) from
immunoglobulin E (IgE)-sensitized effector cells (mast cells and basophils) when cell-bound IgE
antibodies interact with allergen. In vitro serum testing for IgE antibodies provides an indication of the
immune response to allergen(s) that may be associated with allergic disease. The allergens chosen for
testing often depend upon the age of the patient, history of allergen exposure, season of the year, and
clinical manifestations. In individuals predisposed to develop allergic disease(s), the sequence of
sensitization and clinical manifestations proceed as follows: eczema and respiratory disease (rhinitis and
bronchospasm) in infants and children less than 5 years due to food sensitivity (milk, egg, soy, and wheat
proteins) followed by respiratory disease (rhinitis and asthma) in older children and adults due to
sensitivity to inhalant allergens (dust mite, mold, and pollen inhalants).
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