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FHRIN
91450
VDER
82048
rate of destruction. HS can result from abnormalities involving several red cell membrane proteins, such
as band 3, spectrin, and ankyrin. Most often HS is diagnosed in childhood, adolescence, or early adult life.
The diagnosis of HS is usually made by a combination of patient and family history, laboratory evidence
of hemolysis, and review of a peripheral blood smear. The osmotic fragility test is usually markedly
abnormal in these cases. However, factors such as age, sex, and medications can affect the osmotic
fragility test. This evaluation combines osmotic fragility testing with a newly developed flow cytometry
assay to provide complementary information in the evaluation of patients with suspected HS.
Useful For: Investigation of suspected hereditary spherocytic hemolytic anemia
Interpretation: An interpretive report will be provided.
Reference Values:
0.50 g/dL NaCl (unincubated)
Males: 0.0-47.8% hemolysis
Females: 0.0-31.1% hemolysis
0.60 g/dL NaCl (incubated)
Males: 18.7-67.4% hemolysis
Females: 10.9-65.5% hemolysis
0.65 g/dL NaCl (incubated)
Males: 4.4-36.6% hemolysis
Females: 0.2-39.3% hemolysis
0.75 g/dL NaCl (incubated)
Males: 0.8-9.1% hemolysis
Females: 0.0-10.9% hemolysis
An interpretive report will be provided.
Clinical References: 1. Gladen BE, Luicens JN: Hereditary spherocytosis and other anemias due to
abnormalities of the red cell membrane. In Wintrobe's Clinical Hematology. 10th edition. Edited by GR
Lee, J Foerester, J Lukens,et al. Baltimore, Williams and Wilkins, 1999 pp 1132-1159 2. Gallagher PG,
Jarolim P: Red cell membrane disorders. In Hematology: Basic Principles and Practice. 3rd edition.
Edited by R Hoffman, EJ Benz, SJ Shattil, et al: New York, Churchill Livingstone, 2000 pp 576-610
Heroin Analysis, Whole Blood
Reference Values:
This specimen was screened by Immunoassay. Any positive result is confirmed by Gas Chromatography
with Mass Spectrometry (GC/MS). The following threshold concentrations are used for this analysis:
Drug Screening Threshold Confirmation Threshold
----------------------------------------------------------------------------------------------
Heroin 10 ng/mL
Morphine 10 ng/mL
6-acetylmorphine 6 ng/mL
Test Performed By: Medtox Laboratories, Inc.
402 W. County Road D
St. Paul, MN 55112
Herpes Simplex Virus (HSV) and Varicella-Zoster Virus (VZV),
Molecular Detection, PCR, Dermal
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