Sorted By Test Name - Mayo Medical Laboratories

5362
FEMA
91836
EMA
9360
anatomic pathology consultation
Interpretation: A neoplastic clone is detected when the percent of nuclei with an abnormality exceeds
the established normal cutoff for the JAZF1 probe set. A positive result of JAZF1 rearrangement is
consistent with a diagnosis of endometrial stromal tumors (EST). A negative result suggests that JAZF1 is
not rearranged, but does not exclude the diagnosis of EST.
Reference Values:
An interpretive report will be provided.
Clinical References: 1. Koontz J, Soreng AL, Nucci M, et al: Frequent fusion of the JAZF1 and
JJAZ1 genes in endometrial stromal tumors. Proc Natl Acad Sci USA 2001;98(11):6348-6353 2. Oliva E,
de Leval L, Soslow RA, et al: High Frequency of JAZF1-JJAZ1 gene fusion in endometrial stromal
tumors with smooth muscle differentiation by interphase FISH detection. Am J Surg Pathol
2007;31(8):1277-1284 3. Nucci R, Harburger D, Koontz J, et al: Molecular analysis of the JAZF1-JJAZ1
gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms. Am J
Surg Pathol 2007;31(1):65-70 4. Huang H-Y, Ladanyi M, Soslow RA: Molecular detection of
JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology-evidence
for genetic heterogeneity. Am J Surg Pathol 2004;28(2):224-232
Endomyocardial Biopsy
Clinical Information: Endomyocardial biopsies may be indicated to evaluate a variety of cardiac
disorders. The procedure is performed using a device inserted through the jugular, subclavian, or femoral
vein.
Useful For: Evaluation of: -Cardiac allograft rejection -Cardiomyopathies -Myocarditis -Idiopathic
arrhythmias -Idiopathic chest pain -Anthracycline cardiotoxicity -Secondary heart disease (amyloidosis,
sarcoidosis, hemochromatosis, storage diseases, and neoplastic diseases)
Interpretation: This request will be processed as a consultation. Appropriate stain(s) will be
performed and a diagnostic interpretation provided.
Reference Values:
Abnormalities will be compared to reported reference values.
Clinical References: Edwards WD, Holmes DR Jr: Transvenous endomyocardial biopsy. In Mayo
Clinic Practice of Cardiology: Fundamentals and Practice. 3rd edition. Edited by ER Giuliani, BJ Gersh,
MD McGooh, et al. St. Louis, MO, Mosby-Yearbook, 1996, pp 672-688
Endomysial (EMA) Antibody (IgG) titer
Reference Values:
Negative: or =1:2.5 titer
Serology Comments
IgG-EMA is generally only significant in those individuals who are IgA deficient and thus cannot
produce IgA-EMA.
Test Performed By: IMMCO Diagnostics, Inc.
60 Pineview Drive
Buffalo, NY 14228
Endomysial Antibodies (IgA), Serum
Clinical Information: Circulating IgA endomysial antibodies (EMA) are present in 70% to 80% of
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