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PN7
83641
Determination of parallelism and nonparallelism in bioassay dilution curves. J Clin Microbiology 1994
October;32:2441-2447 7. Plikaytis BD, Goldblatt D, Frasch CE, et al: An analytical model applied to a
multicenter pneumococcal enzyme-linked immunosorbent assay study. J Clin Microbiology 2000
June;38(6):2043-2050
Streptococcus pneumoniae IgG Antibodies, 7 Serotypes, Serum
Clinical Information: Streptococcus pneumoniae causes infectious diseases in children and adults,
including invasive infections (eg, bacteremia and meningitis) and infections of the respiratory tract (eg,
pneumonia and otitis media).(1,2) Streptococcus pneumoniae is responsible for approximately 40,000
deaths and 500,000 cases of pneumonia annually in the United States. There are more than 90 serotypes of
Streptococcus pneumoniae. The serotypes responsible for disease vary with age and geographic location.
In children younger than 6 years, 7 serotypes (4, 6B, 9V, 14, 18C, 19F, and 23F) account for 80% of
invasive disease and up to 100% of all isolates that are highly resistant to treatment with penicillin.(3,4)
The greatest risk of invasive infection with Streptococcus pneumoniae occurs in children 2.8
14 (14) >5.2
18C (56) >2.7
19F (19) >1.7
23F (23) >2.9 Serotype results within the normal value range are
consistent with a normal humoral immune response to 7-valent
conjugate vaccine.
Clinical References: 1. Schuchat A, Robinson K, Wenger JD, et al: Bacterial meningitis in the
United States in 1995. N Engl J Med 1997;337:970-976 2. Zangwill KM, Vadheim CM, Vannier AM, et
al: Epidemiology of invasive pneumococcal disease in Southern California: implications for the design
and conduct of a pneumococcal conjugate vaccine efficacy trial. J Infect Dis 1996;174:752-759 3. Butler
JC, Breiman RF, Lipman HB, et al: Serotype distribution of Streptococcus pneumoniae infections among
preschool children in the United States, 1978-1994: implications for development of a conjugate vaccine.
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