Sorted By Test Name - Mayo Medical Laboratories

TPNT
82428
TROT
82788
"Tropheryma whippleii " and its use for detection of "T. whipplei" in clinical specimens by PCR. J Clin
Microbiol 2000;38:2248-2253 3. Sloan LM, Rosenblatt JE, Cockerill FR 3rd. Detection of Tropheryma
whipplei DNA in clinical specimens by LightCycler real-time PCR. J Clin Microobiol. 2005;43:3516-8 4.
von Herbay A, Ditton HJ, Schuhmacher F, et al: Whipple's disease: staging and monitoring by cytology
and polymerase chain reaction analysis of cerebrospinal fluid. Gastroenterology 1997;113(2):434-441
Troponin T, Serum
Clinical Information: Troponin T is a myofibrillar protein found in striated musculature. There are 2
types of myofilament, a thick filament containing myosin and a thin filament consisting of 3 different
proteins: actin, tropomyosin, and troponin. Troponin is itself a complex of 3 protein subunits: troponin T,
troponin I, and troponin C. Troponin T binds the troponin complex to tropomyosin. Troponin I inhibits
actomyosin ATPase in relation to the calcium concentration. Troponin C, with its 4 binding sites for
calcium, mediates calcium dependency. In the cytosol, troponin T is found in both free and protein-bound
forms. The unbound (free) pool of troponin T is the source of the troponin T released in the early stages of
myocardial damage. Bound troponin T is released from the structural elements at a later stage,
corresponding with the degradation of myofibrils that occurs in irreversible myocardial damage. The most
common cause of cardiac injury is myocardial ischemia, ie, acute myocardial infarction. Troponin T
becomes elevated 2 to 4 hours after the onset of myocardial necrosis, and can remain elevated for up to 14
days. Elevations in troponin T are also seen in patients with unstable angina. The finding of unstable
angina and an elevated troponin T are known to have adverse short- and long-term prognoses, as well as a
unique beneficial response to an invasive interventional strategy and treatment with the newer antiplatelet
agents and low-molecular-weight heparin.
Useful For: Exclusion diagnosis of acute myocardial infarction Monitoring acute coronary syndromes
and estimating prognosis Possible utility in monitoring patients with nonischemic causes of cardiac injury
Troponin T is the cardiac marker of choice for the Mayo Health System for the evaluation of patients with
possible cardiovascular injury
Interpretation: The upper limit for normal individuals is or =0.01 ng/mL that are
rising make the diagnosis of cardiac injury. Decreasing values are indicative of recent cardiac injury.
Troponin T values > or =0.01 ng/mL are a prognostic sign in patients with ischemic heart disease and
most other situations. Clinical judgment is necessary to distinguish patients who have ischemic heart
disease from those who do not. However, all patients with > or =0.01 ng/mL troponin T are at increased
risk for cardiac events relative to patients with undetectable troponin T. Patients with low level ( or =0.01 ng/mL
troponin T are at increased risk for cardiac events relative to patients with undetectable troponin T.
Reference Values:
or =0.01 ng/mL have been shown to have prognostic value.
Clinical References: Jaffe AS: 2001-A biomarker odyssey. Clin Chim Acta 1999;284:197-211
Trout, IgE
Clinical Information: Clinical manifestations of immediate hypersensitivity (allergic) diseases are
caused by the release of proinflammatory mediators (histamine, leukotrienes, and prostaglandins) from
immunoglobulin E (IgE)-sensitized effector cells (mast cells and basophils) when cell-bound IgE
antibodies interact with allergen. In vitro serum testing for IgE antibodies provides an indication of the
immune response to allergen(s) that may be associated with allergic disease. The allergens chosen for
testing often depend upon the age of the patient, history of allergen exposure, season of the year, and
clinical manifestations. In individuals predisposed to develop allergic disease(s), the sequence of
sensitization and clinical manifestations proceed as follows: eczema and respiratory disease (rhinitis and
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